background: prostate cancer (pca) is an important health problem in the aging male population in the world. it is the third most common cancer in the world. despite of its importance, relatively little is known about its etiology. sexually transmitted infections (sti) and urogenital pathogens such as mycoplasma and ureaplasma, have been proposed as a risk factor for prostate cancer development....

Prometastatic gene expression events occur during the early phases of prostate oncogenesis, even though overlaping with genes that induce primary cancer growth. Cytogenetic and genomic profiling analyses have identified many cancer-associated chromosomal abnormalities consisting mainly in losses in the early phases of sporadic primary prostate carcinoma. Metastatic genes are those in which gain...

prostate cancer is the second most common cancer in men. in spite of on-going researches in this filed, the specific causes of prostate cancer are so far unknown. in this study, we used two methods of gene set analysis to improve the biological interpretation of the observed expression patterns in prostate cancer. the gene set analysis is a computational method to discover gene sets whose expre...

  Background: Prostate cancer is one of the leading causes of cancer deaths among men. New gene expressed in prostate (NGEP), is a prostate-specific gene expressed only in normal prostate and prostate cancer tissue. Because of its selective expression in prostate cancer cell surface, NGEP is a potential immunotherapeutic target. To target the NGEP in prostate cancer, it is essential to investig...

background: the aim of this study was to evaluate over expression of epidermal growth factor receptor (egfr) gene in localized prostate cancers and determine its relation with clinical and pathological factors affecting the progression of the disease. methods: in the tissue samples of the patients with prostate cancer undergoing radical prostatectomy, egfr expression was evaluated by immunohist...

Background: Prostate cancer is the second most common cancer among men after lung cancer. Prevention of death from prostate cancer by increasing knowledge and attitude is possible. The purpose of this study was to assess knowledge, attitude and practice of men pensioners in Ahvaz city towards prevention of prostate cancer. Materials and Methods: This descriptive study was conducted on 1000 pens...

Recent admixture mapping and linkage/association studies have implicated an approximately 1 Mb region on chromosome 8q24 in prostate cancer susceptibility. In a subsequent follow-up investigation, Haiman et al. (Nat Genet 2007;39:638-44) observed significant, independent associations between 7 markers within this region and sporadic prostate cancer risk in a multi-ethnic sample. To clarify the ...

  Abstract   Background: Regarding the variety of tests present for detecting and also screening   prostate cancer and also bearing in mind the advantages and disadvantages of   these tests we decided to re-evaluate these tests (total prostate specific antigen and all   of its modifications) in detecting prostate cancer in men with intermediate serum   PSAlevels.   Methods: Following a cross se...