Predictive modeling is an available tool to assess worker exposures to a variety of chemicals in different industries and product-use scenarios. The European Chemical Agency (ECHA)'s guidelines for manufacturers to fulfill the European Union's legal requirements pursuant to the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) initiative include recommendations for t...

This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging were also conducted. The resu...

Spray atomization is a common process found in different industries, where sprays under high injection pressure are widely recorded in the literature. Nonetheless, research on spray breakup mechanism under low pressure in pharmaceutical industry is still relatively rare. Numerical model in the Lagrangian approach was modified for simulating the spray formation from a nasal spray device in the c...

This study investigates a new concept of producing precipitated calcium carbonate (PCC) from steelmaking slag and carbon dioxide via a spray carbonation process. The presented laboratory-scale spray carbonation test reactor uses a spray nozzle to disperse fine droplets of a Ca-rich solution into a spray tower, where calcium carbonate precipitates as a result of the reaction between calcium and ...

BACKGROUND Cluster headache is a form of primary headache in which attacks are rapid in onset with very severe pain. The mainstays of acute therapy are inhaled oxygen and sumatriptan succinate injection. OBJECTIVE To evaluate zolmitriptan nasal spray in the acute treatment of cluster headache. METHODS Ninety-two patients, aged 40 +/- 10 years (mean +/- SD) (80 men and 12 women), with Intern...