Pathogenic protein accumulation and spread are fundamental principles of neurodegenerative diseases and ultimately account for the atrophy patterns that distinguish these diseases clinically. However, the biological mechanisms that link pathogenic proteins to specific neural network damage patterns have not been defined. We developed computational models for mechanisms of pathogenic protein acc...

Microgravity experiments on flame spread over thermally-thick fuels were conducted using foam fuels to obtain low density and thermal conductivity, and thus large spread rate (Sf) over thermally-thick fuels compared to dense fuels such as PMMA. This scheme enabled meaningful results to be obtained even in 2.2 second drop tower experiments. It was found that, in contrast conventional understandi...

The introduction and spread of invasive species is increasingly driven by the expansion of human-made transportation routes. We formulate a network model of biotic invasion incorporating logistic growth and dispersal along a network, and present analyses of the model. We introduce small world networks and use them to investigate the role of network properties and long-distance dispersal on spre...