background: recent studies have indicated potential of saffron for applying in a wide variety of diseases such as psychiatric and neurologic disorders. the concurrent use of saffron with ssris can lead to reducing the dose of ssris. saffron at a dose of 200 mg may change some hematological and biochemical parameters. objective: the goal of this trial was to assess the safety of concomitant admi...

Depression is a serious illness that affects 20.9 million Americans a year. The most common method of treatment is selective serotonin reuptake inhibitors (SSRIs). Previous studies have shown that SSRI efficacy is limited. This review of current clinical data combined with statistical analyses has shown that the efficacy of SSRI treatment in adolescents is even more limited. It also has shown t...

In this case series we report four cases of patients with Down syndrome with symptoms consistent with obsessive compulsive disorder. Each patient experienced substantial reduction in compulsive behaviors with pharmacotherapy of an SSRI alone or with the addition of risperidone to SSRI therapy. None of the patients experienced significant side effects. This small case series supports the use of ...

Lutz P.-E. Multiple serotonergic paths to antidepressant efficacy. J Neurophysiol 109: 2245–2249, 2013. First published January 23, 2013; doi:10.1152/jn.01093.2012.—Depression is a leading cause of disability worldwide. Brain mechanisms underlying the clinical antidepressant efficacy of selective serotonin reuptake inhibitors (SSRI), currently the first-line treatment, remain poorly understood....

To the Editor: Pathological stealing is kleptomanic behavior due to brain disease. As with kleptomania, there is an inability to resist stealing unneeded objects of insignificant value.1 Kleptomania may be related to obsessive-compulsive disorder (OCD) and could respond to selective serotonin reuptake inhibitor (SSRI) medications, the treatment of choice for OCD.2,3 Herein, we report 4 frontote...

Aims Serotonin in platelets has a major role promoting vasoconstriction and platelet aggregation. Selective serotonin reuptake inhibitors (SSRIs), which are widely used clinically, inhibit the transporter responsible for uptake into platelets. This depletion reduces clot formation, thus increasing bleeding risk. risk is particularly elevated older adults who also more likely to have co-morbid p...

Patients are often required to “cross over” between selective serotonin reuptake inhibitors (SSRIs) because of cost savings or a lack of the agent’s effectiveness. Pharmacokinetics, serotonin syndrome, and withdrawal symptoms must be considered when therapy is changed. This review analyzes the data available regarding changing from one SSRI to another; however, the findings are inconclusive in ...

The aim of the present study was to retrospectively identify sexual dysfunction changes in the patients under mirtazapine-augmented serotonin reuptake inhibito (SSRI) treatment. The study comprised medical records of 20 outpatients, under mirtazapine-augmented SSRI treatment for their major depressive disorder, who had been selected among the patients that had developed sexual dysfunction to pr...

Anecdotal and published case reports suggest that some patients taking selective serotonin reuptake inhibitors (SSRI) experience diminution in emotional responsiveness. This study aims to define the individual components of emotion disturbed in these patients. Fifteen patients reporting SSRI-induced sexual dysfunction completed the Laukes Emotional Intensity Scale (LEIS), a questionnaire about ...