Dear Editor: Nausea appears to be a dosagerelated side effect in as many as 26% of patients treated with selective serotonin reuptake inhibitors (SSRIs) (1,2). SSRIs increase the concentration of serotonin (5-HT) at neuronal synapses. Emesis may result from subsequent activation of central or peripheral 5-HT3 receptors (2,3). Antagonism of 5-HT3 by drugs like ondansetron is known to reduce emes...

BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) are widely prescribed for mood and anxiety disorders. However, it is not clear whether SNRIs are more strongly associated with cardiovascular and cerebrovascular events than SSRIs. METHODS This was a propensity score-matched, population-based, cohort study of Manitobans who star...

OBJECTIVE The purpose of this article was to systematically compare the developmental trajectory of neurobehavior over the first postnatal month for infants with prenatal exposure to pharmacologically untreated maternal depression, selective serotonin reuptake inhibitors or serotonin and norepinephrine reuptake inhibitors (collectively: SSRIs), SSRIs with concomitant benzodiazepines (SSRI plus ...

Cover picture: Summation PET images of an untreated reference subject (left) and of a patient treated with an SSRI (citalopram, right), after intravenous injection of [ 11 C]MADAM. All previously published papers were reproduced with permission from the publisher. ABSTRACT The serotonin system has been implicated in major depression since the 1960s, mainly based on the serotonin enhancing prope...

Introduction Early ejaculation is besides erectile dysfunction the most common exual amog males. It can create suffering and inflence relationships. Selective serotonin reuptake inhibitors has known side effect sometimes are used as treatment for early ejaculation. Objectives To present successful off-label of Methods Case report. Two cases. Results male patientes with problems that influenced ...

Depression is a major psychiatric disorder. It affects millions of people worldwide and inflicts tremendous economic burden on societies. The advent of selective serotonin re-uptake inhibitors as antidepressants has been a revolutionary advance in the treatment of depression and related disorders. However, selective serotonin re-uptake inhibitors are also associated with several undesirable pro...

Serotonin syndrome is a rare but potentially fatal adverse drug reaction associated with increased serotonergic activity in the central nervous system. It is characterized by a triad of symptoms, which include altered mental status, neuromuscular hyperactivity, and autonomic instability or hyperactivity. Due to the potential of rapid onset, it is important for clinicians to recognize the signs ...

BACKGROUND Serotonin syndrome is a mild to potentially life-threatening syndrome associated with excessive serotonergic activity within the central nervous system. Serotonin syndrome is associated with medication use, drug interactions, and overdose. While serotonin syndrome is often associated with the use of selective serotonin inhibitors (SSRI), an increasing number of reports are being pres...

BACKGROUND It is not clear if the frequency of deliberate self-harm (DSH) is the same in patients taking different pharmacological classes of antidepressant drugs. AIMS To compare the frequency of DSH in patients who had been prescribed a tricyclic antidepressant (TCA) or a selective serotonin reuptake inhibitor (SSRI) prior to the DSH event. METHOD This was a prospective study in 2776 cons...

p11, through unknown mechanisms, is required for behavioral and cellular responses to selective serotonin reuptake inhibitors (SSRIs). We show that SMARCA3, a chromatin-remodeling factor, is a target for the p11/annexin A2 heterotetrameric complex. Determination of the crystal structure indicates that SMARCA3 peptide binds to a hydrophobic pocket in the heterotetramer. Formation of this complex...