BACKGROUND Dogs and humans with atopic dermatitis (AD) are predisposed to colonization and recurrent infection with Staphylococcus spp. Studies in humans suggest that staphylococcus-specific immunoglobulin E (IgE) plays a key role in disease pathogenesis. Few such studies have been undertaken in dogs. HYPOTHESIS/OBJECTIVES The aim of this study was to compare levels of staphylococcus-specific...

The extent to which acquired immunity participates in protecting against staphylococcal infection is not clear. Considerable evidence would suggest that antibody to the staphylococcus and its products plays only a secondary role in modifying the nature of the lesion produced by the organism, and that nonspecific factors may be more important in determining host susceptibility (1). I t has been ...

Isolated infection of the subacromial bursa is a rare entity. We present the case of a previously fit man who was found to have staphylococcal infection of the sub-acromial bursa, without an obvious precipitant. Preoperative MRI scanning determined the specific locus of infection, and the patient was successfully treated with arthroscopic washout of the sub-acromial bursa followed by empirical ...

Sera from 56 patient and normal adults were examined to quantitate total immunoglobulin E (IgE) and IgE antibodies to Staphylococcus aureus and Staphylococcus epidermidis. Patients were divided into six groups based on clinical symptoms; a seventh group consisted of normal adults. Anti-S, aureus IgE binding was significantly higher in three groups of patients (those with eczema, those with or w...

UNLABELLED Staphylococcus aureus infection is not associated with the development of protective immunity, and disease relapses occur frequently. We hypothesize that protein A, a factor that binds immunoglobulin Fcγ and cross-links V(H)3 clan B cell receptors (IgM), is the staphylococcal determinant for host immune suppression. To test this, vertebrate IgM was examined for protein A cross-linkin...

OBJECTIVES To identify the prognostic markers of a bad outcome in a large population of 104 patients with prosthetic valve endocarditis (PVE), and to study the influence of medical versus surgical strategy on outcome in PVE and thus to identify patients for whom surgery may be beneficial. DESIGN Multicentre study. METHODS AND RESULTS Among 104 patients, 22 (21%) died in hospital. Factors as...

INTRODUCTION Staphylococcal sepsis is one of the most serious bacterial infections in the world, in most cases accompanied by metastatic foci in various organ systems. OBJECTIVE analyze the metastatic foci patients suffering from staphylococcal sepsis. PATIENTS AND METHODS we analyzed the patients treated for staphylococcal sepsis during the ten year period. RESULTS 67 patients were inclu...

Childhood exanthemata are caused by a broad spectrum of common pathogens. Many exanthemata initially present very similarly, even though caused by different organisms, ranging from virus to bacteria and their respective toxins. In the majority of cases the diagnosis is only of academic value, since therapy does hardly differ. However, in some cases accurate and prompt diagnosis is paramount, si...

Staphylococcus aureus is a leading cause of human skin infections, contributing to disease in both healthy and immunocompromised individuals, also complicating burn and surgical wound sites and lesions of atopic dermatitis (Lowy, 1998; Ong and Leung, 2010). Host defense against staphylococcal skin infection is multifaceted, relying on local immunologic control through TH17 and IL-1β–driven recr...