We consider an information theoretic model of a communication channel with a time-varying probability law. Specifically, our model consists of a state dependent discrete memoryless channel, in which the underlying state process is independent and identically distributed with known probability distribution, and for which the channel output at any time instant depends on the inputs and states onl...

Kinetics of single voltage-dependent Shaker potassium channels expressed in Xenopus oocytes were studied in the absence of fast N-type inactivation. Comparison of the single-channel first latency distribution and the time course of the ensemble average current showed that the activation time course and its voltage dependence are largely determined by the transitions before first opening. The op...

Gating properties of Na(+) channels are the critical determinants for the state-dependent block by class I antiarrhythmic drugs; however, recent site-directed mutagenesis studies have shown that the Na(+) channel selectivity filter region controls drug access to and dissociation from the binding site. To validate these observations, we have exploited a naturally occurring cardiac Na(+) channel ...

Vehicular Networked Systems (VNS) are mobile ad hoc networks where vehicles exchange information over wireless communication networks to ensure safe and efficient operation. It is, however, challenging to ensure system safety and efficiency as the wireless channels in VNS are often subject to state-dependent deep fades where the data rate suffers a severe drop and changes as a function of vehic...

introduction numerous studies have demonstrated the presence of potassium selective channels in membranes internal organelles. these channels are essential to a large variety of cellular processes including intracellular 2+ a signaling, protein recycling, charge neutralization and cell protection. in contrast to the sarcoplasmic reticulum + here potassium channels have been clearly identified, ...

Certain drugs evidently exert their therapeutic effects via sodium channel inhibition: local anesthetics, class I antiarrhytmics and certain anticonvulsants. Novel sodium channel inhibitor compounds are actively investigated for other indications involving stroke, ischemia, various neurodegenerative conditions and pain syndroms. All these drugs cause voltage-and use-dependent inhibition of sodi...

Introduction: we have recently reported the presence of two potassium currents with 598 and 368 pS conductance in the rough endoplasmic reticulum (RER) membrane. The 598 pS channel was voltage dependent and ATP sensitive. However, the 368 pS channel was rarely observed and its identity remained obscure. Since cationic channels in intracellular organelles such as mitochondria and RER play imp...

A finite element analysis (FEA) model has been constructed to predict the thermo-fluidic and optical properties of a microstructure optical fiber (MOF) accounting for changes in external temperature, input water velocity and optical fiber geometry. Modeling a water laminar flow within a water channel has shown that the steady-state temperature is dependent on the water channel radius while inde...

The blocking mechanism of the Na+ channel by penticainide, a disopyramide analogue, was studied in rabbit cardiac Purkinje fibers. Na+ channel activity was measured directly by recording the slowly inactivating Na+ current or indirectly by measuring Vmax. The two-microelectrode technique was used to measure currents under voltage-clamp conditions or to impose different degrees and durations of ...

Communication over a quantum channel that depends on state is considered when the encoder has side information (CSI) and required to mask from decoder. A full characterization established for entanglement-assisted masking equivocation region with maximally correlated state, regularized formula given capacity-leakage function without assistance. For Hadamard channels assistance, we derive single...