Genuine heteroleptic neodymium and samarium complexes of formula [Cp*'Ln[(p-tol)NN](BH4)] (Cp*' = C5Me4(nPr), (p-tol)NN = (p-tol)NC(Me)CHC(Me)N(p-tol), Ln = Sm: 1a, Ln = Nd: 1b) have been synthesized for the first time. These unprecedented homologues of early lanthanocenes are prepared by a metathetic reaction between their monocyclopentadienylbisborohydrido precursors with the corresponding po...

Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine....

Abstract We report the enantioselective total syntheses of preussomerins EG 1 , 2 and 3 . The key transformation is a stereospecific photochemical reaction involving 1,6‐hydrogen atom transfer to achieve retentive replacement C−H with C−O bond, enabling otherwise‐difficult control spiroacetal stereogenic center.

The living isospecific-cis-1,4-polymerization and block-copolymerization of (E)-1,3-pentadiene with 1,3-butadiene have been achieved for the first time by using cationic half-sandwich scandium catalysts.

Herein we disclose an iron-catalyzed cross-coupling reaction of propargyl ethers with Grignard reagents. The was demonstrated to be stereospecific and allows for a facile preparation optically active allenes via efficient chirality transfer. Various tri- tetrasubstituted fluoroalkyl can obtained in good excellent yields. In addition, reagents α-alkynyl oxetanes tetrahydrofurans is disclosed her...

liquiritigenin is a chiral flavonoid present in plant based food, nutraceuticals, and traditional medicines. it is also an important ingredient present in licorice. the purpose of this study is to explore the pharmacological activity of racemic liquiritigenin utilizing several in vitro assays with relevant roles in colon cancer and diabetes. where possible, the pure enantiomers were tested to i...

A stereospecific nucleophilic substitution between tertiary alkyl bromides and alcohols is described in the Research Article on page 4329 by Toshiki Nokami, Takashi Koike, Manabu Abe, Eiji Shirakawa, Nishikata, co-workers. The entering alcohol formally attacks C−Br bond to undergo a retentive with formation of ethers.

The rearrangement of 1-alkynyl cyclobutanols and cyclopropanols to alkylidene cycloalkanones catalyzed by cationic triarylphosphine gold(I) complexes is described. The reaction tolerates terminal alkynes as well as alkyl, aryl, and halo-substitution at the acetylenic position and stereoselectively provides a single olefin isomer. The gold(I)-catalyzed rearrangement is stereospecific with regard...

Certain 3-azabicyclo[3.3.1]nonane derivatives undergo unprecedented stereospecific skeletal cleavage when subjected to light affording a novel heterotricyclic skeleton.

Enzymes such as lipases and proteases have been used catalysts in nearly anhydrous organic solvents diisopropyl ether hexane to carry out stereospecific selective enzymatic resolutions of carboxylic acid derivatives 2-bromohexadecanoic acid, which may be for prevention treatment bone loss-related diseases β-phenyllactic has a role human metabolite.