BACKGROUND The aim of the study was to evaluate the efficacy and safety of small surface steroid-eluting atrial and ventricular pacing leads in comparison to non-steroid leads using remote monitoring system (Biotronik Home Monitoring®). METHODS In this randomized multicenter prospective trial, SIELLO T steroid-eluting ventricular leads (n = 42) were compared to BPPU T non-steroid leads (n = 4...

BACKGROUND The side effects of steroid are serious problems in renal transplant patients. However, withdrawal of steroid has been controversial. We evaluated the benefits and risk of early steroid withdrawal after renal transplantation. PATIENTS AND METHODS The outcomes of early steroid withdrawal from triple immunosuppressive drug therapy were analyzed in four living related and one cadaveri...

Background and study aims: One of the major complications after endoscopic resection (ER) for large superficial esophageal squamous cell carcinoma (ESCC) is benign esophageal stricture, which can reduce quality of life even if ESCC achieves a cure without organ resection. Recently, steroid administration has been reported as a prophylactic treatment to prevent esophageal strictures. This retros...

PURPOSE This study investigated clinical values of corticosteroid (CS) receptor α and β in the nasal mucosa of patients with allergic rhinitis (AR) by determining CS receptor α and β mRNA expression following steroid treatment. PROCEDURES Among 120 outpatients, 65 had persistent AR, including 36 being sensitive to steroid treatment (steroid-sensitive group) and 29 being resistant to steroid t...

Steroid responsiveness of peripheral blood T cells derived from steroid sensitive, steroid dependent, and steroid resistant asthmatics, and induction of steroid resistance by costimulatory signal Akio Mori, Akemi Abe, Satoshi Kouyama, Miyako Yamaguchi, Yo Iijima, Chihiro Mitsui, Chiyako Oshikata, Hidenori Tanimoto, Kiyoshi Sekiya, Takahiro Tsuburai, Masami Taniguchi, Mamoru Ohtomo, Yuji Maeda, ...

Steroid merupakan senyawa metabolit sekunder, steroid dapat digunakan sebagai antioksidan dan anti kanker. Penelitian ini bertujuan untuk menentukan kadar pada buah, tepung biskuit labu siam menggunakan metode ekstraksi maserasi, penentuan alat spektrofotometer UV-Vis. Hasil penelitian menunjukkan bahwa adanya masing-masing sampel yaitu buah sebesar 0.235±0.03 gram/100 g, 0.435±0.02 0.556±0.04 g.

Corticosteroid administration has been widely used as the empirical treatment for various inner ear diseases such as sudden sensorineural hearing loss (SNHL), Meniere disease, and autoimmune-induced hearing loss for a long time. After Sakata et al. [1] first tried intratympanic (IT) steroid injection to control Meniere disease, IT steroid injection treatment has been used as an alternative opti...

Esophageal stricture is a severe adverse event after circumferential endoscopic submucosal dissection (ESD). Steroid administration is a new method to prevent stricture formation. We performed a meta-analysis to investigate the efficacy and safety of steroid administration to prevent esophageal stricture after circumferential ESD. PubMed, the Cochrane Library, EMBASE, Chinese Biomedical Databas...

This study aimed to investigate the activities of novel 20(R)-3,20-dihydroxy-19-norpregn-1,3,5(10)-trienes (kuz7 and kuz8b) natural 13β- epimeric 13α-series against triple-negative MDA-MB-231 breast cancer cells. High antiproliferative activity synthesized compounds kuz8b kuz7 cells was revealed. The steroid 13β-configuration more active than 13α-steroid kuz8b. Cell cycle analysis revealed comm...