introduction: the aim of this study was to evaluate the efficacy of combined intratympanic and systemic steroid therapy compared with systemic steroid therapy alone in idiopathic sudden sensorineural hearing loss (issnhl) patients with poor prognostic factors.     materials and methods: seventy-seven patients with sudden sensorineural hearing loss (ssnhl) who had at least one poor prognostic fa...

1. [4-(14)C]Testosterone was administered to anaesthetized male and female New Zealand White rabbits as a single injection or as a 45-60min. infusion. 2. After a single dose a total of approx. 56-80% of the radioactivity was excreted in bile and urine. After infusion total recovery of radioactivity was approx. 63-75%. 3. The mean ratio of metabolites in urine to those in bile was 0.77+/-0.41 (r...

Toluene/o-xylene monooxygenase hydroxylase (ToMOH), a diiron-containing enzyme, can activate dioxygen to oxidize aromatic substrates. To elucidate the role of a strictly conserved T201 residue during dioxygen activation of the enzyme, T201S, T201G, T201C, and T201V variants of ToMOH were prepared by site-directed mutagenesis. X-ray crystal structures of all the variants were obtained. Steady-st...

A cetylcholinesterase (A chE) can be induced in a non-neuronal, epithelial cell line from Chi­ ronomus tentans by the m oulting horm one 20-OH-ecdysone. M aximal response is reached a ft­ er 7 days. The increase in enzym atic activity can be suppressed by sim ultaneous incubation with inhibitors o f transcrip tion and translation . The potency o f various steroid horm ones to induce AchE coinci...

Blood samples can be difficult to obtain in studies involving serial sampling, especially in developing countries where there may also be logistic, ethical, and cultural constraints that make frequent blood collection impractical. Assays for steroids in saliva may avoid some of these difficulties. A multicenter study involving laboratories in five countries was carried out to compare the result...

Regulatory modifications of steroidogenesis were induced following the administration on rats and humans of a nutritive supplement, Humanofort, containing two embryonary peptides (EP) of 5 and 10 kDa. The administration of EP to rats for 60 days increased significantly the urinary excretion of 17-ketosteroids in all animals. The serum cholesterol increased only in females, by ~50%, this increas...

The steroid hormones are lipophilic compounds with low molecular weight, derived from cholesterol, which play a crucial role in differentiation, development and physiological functions of many tissues. They are synthesized primarily by endocrine glands, such as the gonads, the adrenal glands and the feto-placental unit during pregnancy. In addition, the central nervous system (CNS) seems to be ...

................................................................................................................................. 5 LIST OF ORIGINAL COMMUNICATIONS........................................................................... 11 ABBREVIATIONS ..................................................................................................................... 13 INTRODUCTION...........

OBJECTIVE The underlying mechanisms of polycystic ovarian syndrome (PCOS) are not fully understood yet. The aim of the study was to get functional insights into the regulation of steroid hormones in PCOS by steroid metabolomics. DESIGN This is a longitudinal study of changes of steroid hormones in 40 obese girls aged 13-16 years (50% with PCOS) participating in a 1-year lifestyle intervention...