نتایج جستجو برای: sterol regulatory elementbinding transcription factor 1
تعداد نتایج: 3558966 فیلتر نتایج به سال:
FDPS (farnesyl diphosphate synthase) catalyses the formation of farnesyl diphosphate, a key intermediate in the synthesis of cholesterol and isoprenylated cellular metabolites. FDPS is also the molecular target of nitrogen-containing bisphosphonates, which are used as bone-antiresorptive drugs in various disorders. In the present study, we characterized the sterol-response element and NF-Y (nuc...
The sterol-sensing domain (SSD) is a ∼180 amino acid long region that is conserved in six families of proteins such as hydroxymethylglutaryl-CoA reductase (HMDH), SREBP (sterol regulatory element binding protein) cleavage activating protein (SCAP), Niemann-Pick C-1 type protein (NPC1), Patched, Patched-related and Dispatched [1]. This domain encompasses five transmembrane helices and is involve...
We have evaluated the mechanism for sterol-regulated gene expression by the sterol regulatory element binding proteins (SREBPs) in intact cells. We show that activation of SREBPs by sterol depletion results in the increased binding of Sp1 to a site adjacent to SREBP in the promoter for the low density lipoprotein (LDL) receptor gene in vivo. Similarly, sterol depletion resulted in the increased...
1999, 19(8):5495. Mol. Cell. Biol. Michael Briggs, Bruce M. Spiegelman and Johan Auwerx Fruchart, Kim, Jamila Najib, Genevieve Martin, Jean-Charles Lluis Fajas, Kristina Schoonjans, Laurent Gelman, Jae B. and Metabolism Implications for Adipocyte Differentiation Regulatory Element Binding Protein 1: and Determination Factor 1/Sterol Expression by Adipocyte Differentiation γ Proliferator-Activat...
Little is known about the protective role of inflammatory processes in modulating lipid metabolism in infection. Here we report an intimate link between the innate immune response to infection and regulation of the sterol metabolic network characterized by down-regulation of sterol biosynthesis by an interferon regulatory loop mechanism. In time-series experiments profiling genome-wide lipid-as...
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