BACKGROUND Methylentetrahydrofolate reductase plays a central role in converting folate to methyl donor for DNA methylation. Genetic variations in folate metabolism are believed to contribute to the risk of acute lymphoblastic leukemia, colon, esophageal and stomach cancer, as well as cardiovascular and cerebrovascular diseases. MTHFR C677T and A1298C polymorphisms are known to be risk factors ...

Background & Aim:According to globally development of stomach cancer especially in Ardabil, Iran, as the second major cause of mortality throughout the world, increased drug-resistant bacteria including Helicobacter pylori as the most important risk factors for stomach cancer, and side effects of antibiotics and chemical drugs normally used to treat. Expe...

astric carcinoma is a malignant disease, which starts in the stomach. Despite declining incidence still remains the second cause of death of all malignancies worldwide. It is a major health problem for two reasons: In Asia, East Europe and developing countries the incidence decreases slowly. In USA and West Europe although incidence decreases sharply, mortality of diagnosed gastric cancer remai...

BACKGROUND Stomach cancer is the fourth most common cancer and the second leading cause of cancer- related death through the world. It is predicted that the number of new cancer cases will be more than 15 million cases by 2020. Regarding the lack of studies on this topic in the country, we have thoroughly examined the patho-epidemiology of stomach cancer in Iran. MATERIALS AND METHODS In this...

BACKGROUND Several genetic variants including PSCA rs2294008 C>T and rs2976392 G>A, MUC1 rs4072037 T>C, and PLCE1 rs2274223 A>G have shown significant association with stomach cancer risk in the previous genome-wide association studies (GWASs). METHODS To evaluate associations of these SNPs in the Han Chinese, an independent hospital based case-control study was performed by genotyping these ...

OBJECTIVE To examine the interaction between salt-intake and helicobacter pylori (H. pylori) infection in the development of stomach cancer in an ecological study of 67 Chinese rural counties. METHODS Stomach cancer mortality data of 67 counties were derived from a national survey conducted in China between 1986 and 1988. Information regarding the prevalence of H. pylori infection and urinary...

Background: Depression and anxiety had negative effects on the quality of life of cancer patients, thus hospital anxiety and depression scale (HADS) is a useful instrument for screening these problems. This research was performed to assess the prevalence of their anxiety and depression. Methods: From 2012-2013, one hundred fifty patients with recent diagnosis of different cancers in Babol, Ira...

The induction of ornithine decarboxylase (ODC), a key enzyme of polyamine biosynthesis, is an early and obligatory event in the tumor-promoting step in animal models. The enzyme activity is also elevated in some human premalignant lesions. We determined the ODC activity in human gastric cancer tissue and in the mucosa of cancer-bearing stomach. We concluded that gastric cancer tissue had signif...

BACKGROUND Smoking has not been confirmed as a risk factor for cancers of the liver and stomach. The authors examined prospectively the relationship between smoking and these cancers in an endemic region. METHODS The data used were a cohort study on the relationship between lifestyle and health in the region having the highest liver cancer mortality in Japan. Of the cohort members, 4050 males...