Oxidative stress injury is one important factor in intestinal mucosal barrier damage. Expression of heat shock protein (HSP)70 is an endogenous mechanism by which living cells adapt to stress. This study was undertaken to investigate the protective effects of HSP70 on intestinal oxidative stress. Two hundred and forty broilers were injected intraperitoneally with HSP70 inducer l-(1)-glutamine o...

AIMS We investigated the effffects and the possible mechanism of microinjection of histamine into cerebellar fastigial nucleus (FN) on stress-induced gastric mucosal damage (SGMD) in rats. The effect of microinjection of histamine into FN on SGMD was observed. METHODS The model of SGMD was established by restraint and water (21 ± 1°C)-immersion (RWI) for 3 h in rats. The gastric mucosal damag...

Hydrogen sulfide (H2S) is a gaseous meditator that has various physiological and pathophysiological roles in the body. It has been shown to be an important mediator of gastrointestinal (GI) mucosal defense and contributes significantly to repair of damage and resolution of inflammation. Synthesis of H2S increases markedly after mucosal injury, and inhibition of H2S in such circumstances leads t...

Absorption of drugs through the oral cavity was noted as early as 1847 and systemic studies of oral cavity absorption were first reported in 1935 [1]. Since then, substantial effort has been focused on drug absorption from a drug delivery system in a particular region of the oral cavity [2-5]. As a site for drug delivery, the oral cavity offers many advantages over other routes of drug administ...

Recent results from our laboratory,'-3 as well as data reported by others,4' have shown that gastroduodenal blood flow functions not only provide 0210 and substrates, but also deliver HCO3 to the mucosa. This may be of particular relevance to the pathogenesis of stress ulceration. Sepsis and haemorrhagic shock are frequently associated with systemic acidosis and reduced arterial HCO3 concentrat...

objective(s): gentamicin is used for the treatment of gram-negative bacterial infections. however, gentamicin administration is limited because of nephrotoxicity. the aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats. materials and methods: thirty two male wistar rats received gentamicin (100 mg/kg, ip), with or without cr...

BACKGROUND Surgical manipulation of the intestine results in generation of oxygen free radicals leading to mucosal damage as evidenced by ultrastructural and biochemical changes. It is likely that the gut-derived mediators can bring about damage to distant organs such as the lung. METHODS Surgical manipulation of the gut was performed by opening the abdominal wall and handling the intestine. ...

We have investigated the role of mitochondria on the development of indomethacin (a non-steroidal anti-inflammatory drug)-induced gastric mucosal apoptosis and associated gastropathy in rat. Transmission electron microscopic studies indicate that indomethacin damages mitochondrial ultrastructure and causes mitochondrial dysfunction as evident from decreased stage-3 respiration, dehydrogenase ac...

UNLABELLED Recent studies have shown that stimulation of cannabinoid 1 (CB1) receptor reduces the area of ischemic myocardial necrosis and affects activity of the digestive tract. The aim of the present study was to check whether the administration of CB1 receptor agonist or antagonist affects the stress-induced gastric ulceration and development of edematous pancreatitis. METHODS Experiments...

Background/Aims This study was aimed at evaluating differences in the effects of repeated water avoidance stress (rWAS) on colonic movement, mucosal mast cell counts, cytokine levels, and visceromotor response (VMR) to colorectal distension (CRD) in rats of both sexes. Methods Wistar rats were divided into stress and no-stress groups. Rats in the stress group were exposed to rWAS (1 hr/day) f...