The house mouse Androgen-binding protein (Abp) gene family is comprised of 64 paralogs, 30 Abpa and 34 Abpbg, encoding the alpha (ABPA) and beta-gamma (ABPBG) protein subunits that are disulfide-bridged to form dimers in secretions. Only 14 Abp genes are expressed in distinct patterns in the lacrimal (11) and submandibular glands (3). We created a knockout mouse line lacking two of the three ge...

In order to study the effects of tannins at histomorphological level, mice were either fed with three structurally different types of tannins (tannic acid, chestnut, and quebracho) or treated with isoproterenol, during 10 days. Acini of parotid and submandibular glands increased significantly, being the increase higher for parotid compared to submandibular glands, and higher in the quebracho co...

Introduction Sialolithiasis is the formation of a calcified mass (sialolith) in the salivary glands. It is said to affect 0.1 to 1% of the population with a male predilection and 30 to 60 years being the most common age. (1)Of all the salivary glands, sialoliths are most commonly found in the submandibular gland (80-95%) (2). This is owing to longer, tortuous Wharton's duct, anti-gravity flow o...

Fifty young adult male and female albino rats were studied for the effect of systemically administered Cyclophosphamide upon chemical carcinogenesis of the submandibular gland. In 1 group of animals, pellets of 9,10-dimethyl-l,2-benzanthracene (DMBA) were implanted into the right submandibular glands. A 2nd group of animals received biweekly i.p. injections of Cyclophosphamide (Cytoxan) in addi...

Mouse submandibular gland prorenin-converting enzyme (PRECE) consists of the two polypeptide chains of 17 and 10 kDa and cleaves mouse Ren-2 prorenin at a dibasic site to yield mature renin. Western blot analysis using an antiserum against this enzyme gave rise to multiple bands in mouse submandibular glands, suggesting that PRECE is a member of a protease family. Partial amino acid sequence an...

The aim of our study was to determine to what degree one-year exposure of female rats to cadmium at a dose of 5, 50 and 100 mg Cd/l affects cell proliferation in the submandibular gland, shown by PCNA and Ki-67 expression. In the present study, we found a positive nuclear reaction for PCNA in single cells in microscopic preparations of control rats. In Group I, an increase was observed in the n...

Introduction A 10-year-old girl developed an enlargement of parotid and submandibular salivary glands and lymph nodes up to 2.5 cm associated with edema of her upper eyelids. In further follow-up, she developed non-palpable, vasculitic skin lesions. She received cephixime, that co-incided with partial regression of lymph nodes. Re-occurrence of vasculitic lesions with bilateral edema of upper e...

BACKGROUND AND PURPOSE MR imaging has been proved to be effective in depicting wide variety of pathologic changes of the salivary gland. Therefore, we evaluated clinical usefulness of MR imaging for sialolithiasis. METHODS Sixteen patients with sialolithiasis of the submandibular gland underwent MR imaging. MR images of the glands were obtained with a conventional (T1-weighted), fast spin-ech...

Pleomorphic adenomas are the most common salivary gland tumours. It is rare to find these tumours in submandibular glands. This case report about a twenty-year old male patient who presented with huge mass on region. The facial disfigurement due tumour was responsible for low self-esteem this young male. treated complete left excision.

INTRODUCTION Large cell neuroendocrine carcinoma in the salivary glands is rare. We report a second case of large cell neuroendocrine carcinoma of the submandibular gland diagnosed at autopsy, and a review of the literature. CASE PRESENTATION A 68-year-old Japanese man was referred to our hospital for thorough investigation of swelling on the right side of his neck. Fine-needle aspiration cyt...