BACKGROUND Multinodular goitre is one of the commonest thyroid diseases encountered in the practice of surgery. The most common surgery being performed for multinodular goitre is subtotal thyroidectomy. Total thyroidectomy is designed to remove all of the thyroid tissue. The objective of this study was to evaluate total thyroidectomy as a primary elective procedure for treatment of multinodular...

UNLABELLED To elucidate the prognostic role of (131)I radioactive iodine therapy (RIT), we conducted a retrospective cohort study analyzing the clinical factors that affect survival of postoperative patients with differentiated thyroid carcinoma (DTC). METHODS We included 198 DTC patients with extrathyroidal extension who received total or near-total thyroidectomy and then RIT in our hospital...

Objective: This study aimed to summarize the experience in diagnosis and surgical treatment for giant goiter. Methods: The clinical features of 66 patients with giant goiter were retrospectively reviewed, and the perioperative management, postoperative complications and treatments were summarized. Results: All the patients received surgical treatment: total thyroidectomy in 46 patients, bilater...

The breast is an unusual site for metastasis from malignant tumors, although it may be the first manifestation of extramammary primary malignancy typically arising in lung, skin (melanoma), ovary, or lymph nodes (lymphoma). Breast thyroid carcinoma extremely rare and take years to develop, as differentiated usually indolent slow-growing metastasizes nodes, lungs, bones. Here, we present case a ...

The authors have developed a highly sensitive sandwich-type enzyme immunoassay (EIA) for serum thyroglobulin using the biotin-avidin system. The sensitivity of this EIA was 0.1 ng/ml. The intra- and inter-assay coefficient of variation was 4-15% and 4-11%, respectively. Human Tg in serum was detectable in 100% of 63 normal subjects, and the normal range was from 2.3 ng/ml to 47.4 ng/ml. The rec...

The patients' views and costs of three different forms of treatment for Graves' hyperthyroidism were investigated. The study comprises 174 patients with Graves' hyperthyroidism who were stratified into two age groups: 20 to 34 years and 35 to 55 years. The younger group was randomly assigned to treatment with antithyroid drug plus thyroxine for 18 months or subtotal thyroidectomy, and in the ol...

Destructive therapy for thyrotoxicosis frequently results in hypothyroidism, necessitating life-long treatment with thyroxine. Antithyroid drug therapy is followed by remission in a considerable proportion of patients and subsequent clinical hypothyroidism is rare. There thus seems to be a strong case for the use of antithyroid drugs as the initial treatment in most thyrotoxic patients under th...