Benzoic acid has been reported to inhibit the oxidation of succinic acid by muscle (l), the oxidation of butyric acid and crotonic acid by liver slices (2), and the oxidation of acetoacetic acid by kidney slices (3). It has also been reported to inhibit the oxygen uptake of liver and kidney slices, diaphragm, minced liver, kidney, and brain (4). In the present work it was found that benzoic aci...

The metabolism of fatty acids involves the production of acetyl coenzyme A and its condensation with oxalacetate for complete oxidation in the citric acid cycle. The availability of oxalacetate can determine the extent of metabolism via the Krebs cycle (1). In the presence of a low level of oxalacetate in the liver, fatty acid metabolism should produce an excess of ketone bodies. Previously (2)...

The current concept of fatty acid metabolism involves the formation of acetyl CoAl and the condensation of acetyl CoA with oxalacetate upon entrance into the tricarboxylic acid cycle. Therefore, a sufficient amount of oxalacetic acid is necessary for the complete oxidation of fatty acids via the tricarboxylic acid cycle, and, if sufficient oxalacetic acid is not present., ketosis results. Previ...

Abstract A simplified and scalable one‐pot process for the anaerobic production of succinic acid using a metabolically engineered Corynebacterium glutamicum strain is demonstrated. With targeted bioprocess optimization, titer 78 g L −1 yield 1.41 mol SA GLC were achieved. Succinic was recovered from neutral fermentation broth by electrochemically induced crystallization applied polybutylene bio...

Benzoic acid has been reported to inhibit the oxidation of succinic acid by muscle (l), the oxidation of butyric acid and crotonic acid by liver slices (2), and the oxidation of acetoacetic acid by kidney slices (3). It has also been reported to inhibit the oxygen uptake of liver and kidney slices, diaphragm, minced liver, kidney, and brain (4). In the present work it was found that benzoic aci...

A chemical characteristic of the feces of diarrheal piglets permits differentiation among piglets receiving antibiotic treatment and those with colibacillosis or dyspepsia. A high concentration of lactic or succinic acid was observed in the diarrheic feces of piglets receiving antibiotic treatments and those with dyspepsia; however, no lactic or succinic acids were detected in piglets with coli...

The matrix tablets of diltiazem hydrochloride were prepared by direct compression using hydroxypropyl methyl cellulose (HPMC) and various amounts (2.5%, 5.0%, 10% and 20%) of citric acid, malic acid and succinic acid. The characterization of physical mixture of drug and organic acids was performed by Infra-red spectroscopy. An organic acid was incorporated to set up a system bringing about grad...

Succinic acid is an industrially important commodity chemical that acts as a precursor to numerous other chemicals. This article explores alternative biochemical route (as opposed the traditional from petroleum), by modeling succinic production plant using Actinobacillus succinogenes , convert renewable sugars of corn stover feedstock. The model developed with SuperPro Designer v9.0 was used ev...