Introduction. Unruptured sinus of valsalva aneurysm (SVA) is a rare congenital anomaly, particularly, when it coexists with a ventricular septal defect (VSD) and aortic regurgitation due to the prolapse of the elongated aortic cusp into the VSD. In this report, we present the case of a 19-year-old young man with VSD challenging in spite of dyspnea and lower limb edema. Presentation of Case. Its...

Fig. 1. (A) CT scan image. CT scan shows giant non-coronary sinus of Valsalva aneurysm with neighbouring structures. Arrows indicate closed aortic valves. Ao: aorta, NC-SVA: non-coronary sinus of Valsalva aneurysm, LV: left ventricle, PA: pulmonary artery. (B) TEE image. Trans-oesophageal echocardiography shows aortic cusps level image of sinus of Valsalva aneurysm. *Arrows show aortic cusps, *...

Phylogenetically new insertions of repetitive sequences may contribute to genome evolution by altering the function of preexisting proteins. One example is the SVA sequence, which forms the C-terminal coding exon of the human leptin receptor isoform 219.1. Here, we report that the SVA insertion into the LEPR locus has occurred after divergence of humans and chimpanzees. The SVA element was inse...

Heterogeneity and latent variables are now widely recognized as major sources of bias and variability in high-throughput experiments. The most well-known source of latent variation in genomic experiments are batch effects-when samples are processed on different days, in different groups or by different people. However, there are also a large number of other variables that may have a major impac...

Real-world requirements such as multiple clock domains and low-power modes of operation, including frequency and voltage scaling, often necessitate gate-level System-on-Chip (SoC) verification environments to complement the standard RTL based simulations. If the verification environment relies on assertion-based checkers to validate grey-box operation then gate-level simulations will also benef...

Several important properties of poly(3-hydroxybutyric-co-3-hydroxyvaleric acids) (P(3HB-co-3HV) depend mainly on the HV unit fraction of the copolymer. Sequential and simultaneous feeding of glucose and valerate were employed to produce P(3HB-co-3HV) in a fed-batch culture of Ralstonia eutropha, and the effects of feeding models on the cell growth, 3HV unit fraction, and copolymer productivity ...

We study the relation between logical contradictions such as p ∧ ¬p and structural contradictions such as p∩ (p · q). Intuitively, we expect the two to be treated similarly, but they are not by PSL, nor by SVA. We provide a solution that treats both kinds of contradictions in a consistent manner. The solution reveals that not all structural contradictions are created equal: we must distinguish ...

The attenuated recombinant Vibrio cholerae O1 vaccine strain CVD 103-HgR, re-developed as PXVX0200, elicits a rapid serum vibriocidal antibody (SVA) response and protects against cholera diarrhea in volunteer challenge studies. We performed a phase 3, placebo controlled, double blind, multi-center study to further assess the safety, immunogenicity, and lot-to-lot consistency of PXVX0200. Adult ...

Study Design Large cohort study. Purpose To clarify spinal sagittal alignment and health-related quality of life (HRQOL) according to sex in volunteers aged >50 years with cervical deformity (CD). Overview of Literature Adult spinal deformities, especially those associated with lumbosacral lesions, are more frequent in females; however, CD is observed to a greater extent in males. Methods...