The GD2 ganglioside is a cell-surface component that appears on the surface of metastatic melanoma cells and is a marker for the progression of the disease. The ME36.1 monoclonal antibody binds to the GD2 ganglioside and has shown potential as a therapeutic antibody. ME36.1 is a possible alternative therapy to radiation, which is often ineffective in late-stage melanoma. The crystal structure o...

The design, synthesis, and biological evaluation of conformationally constrained coumermycin A1 analogues are reported. Compounds were evaluated against both breast cancer (SKBr3 and MCF7) and prostate cancer (PC3 mm2, A549, and HT29) cell lines. Non-noviosylated coumermycin A1 analogues that manifest potent antiproliferative activity resulting from Hsp90 inhibition are provided, wherein replac...

BACKGROUND & OBJECTIVES A cyclic lipopeptide (CLP), surfactin produced by a strain of Bacillus subtilis subsp. subtilis (VCRC B471) was found to exhibit mosquitocidal activity. The present study was carried out to enhance the surfactin level using low cost material in the production medium. METHODS Two carbon sources, glucose and common sugar, and two nitrogen sources, ammonium nitrate and so...

FucP of Escherichia coli catalyzes L-fucose/H(+) symport, and a crystal structure in an outward-facing conformation has been reported. However, nothing is known about FucP conformational dynamics. Here, we show that addition of L-fucose to purified FucP in detergent induces ∼20% quenching of Trp fluorescence in a concentration-dependent manner without a shift in λ(max). Quenching is essentially...

Cite as: Matthews F. The use of sugar free chewing gum as a supplement in the prevention of dental caries. Narrative Review. J Oral Res 2015; 4(2): 129-136. Abstract: Dental caries is one of the most prevalent diseases. The WHO has classified it as one of the major public health problems worldwide. That is why a special emphasis has been paid to developing new preventive methods and the use of ...

The application of metabolic engineering in Escherichia coli has resulted in the generation of strains with the capacity to produce metabolites of commercial interest. Biotechnological processes with these engineered strains frequently employ culture media containing glucose as the carbon and energy source. In E. coli, the phosphoenolpyruvate:sugar phosphotransferase system (PTS) transports glu...

The growing interest on the replacement of synthetic antioxidants with natural ones has directed many research toward the plant-derived raw materials. The special attention is focused on inexpensive or residual sources from food agricultural industries. Fruit peels are valuable wastes obtained from domestic and industrial sources. The potential of fruit wastes as sources of natural antioxidants...

A new boiling system for the production of improved VHP sugar is proposed. This modified scheme requires only minor changes to pipe-work in the factory and it is estimated that steam consumption will only be increased marginally.

This study investigated the different performance levels of the workers in the Chittoor Sugar factory located at the Chittoor town of South India. It was also studied how the factors education and work experience influence the performance levels of the workers in the firm. Upon study it has been understood that the two variables under investigation have direct effect on the performance of the w...