McNulty, Patrick H., Nicholas King, Sofia Scott, Gretchen Hartman, Jennifer McCann, Mark Kozak, Charles E. Chambers, Laurence M. Demers, and Lawrence I. Sinoway. Effects of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization. Am J Physiol Heart Circ Physiol 288: H1057–H1062, 2005; doi:10.1152/ajpheart.00625.2004.— Patients with heart disease ...

You are the medical director of your local hospice. After the annual budget review, the hospice’s director comes to you to see if there are treatments being given that are not supported by evidence. In particular, use of supplemental home oxygen was identified as a significant expenditure. The director asks your opinion about whether supplemental oxygen is likely to relieve shortness of breath ...

BACKGROUND A number of studies have shown that COPD, particularly in its later and more severe stages, is associated with various cognitive deficits. Thus, the primary goal of the present study was to elucidate the extent of cognitive impairment in patients with long-term oxygen therapy-dependent (LTOTD) COPD. In addition, this study aimed to determine the effectiveness of two cognitive screeni...

Background Magnetic resonance (MR) T1 relaxation time measurements are increasingly used for myocardial tissue characterization. Significant differences in native and gadolinium-enhanced measurements have been associated with ischemic and non-ischemic cardiomyopathies, myocardial fat deposition, fibrosis and edema as well as regional and global ventricular functional parameters. Supplemental ox...

Introduction EPH-ephrin interactions have important roles in cell adhesion-based process during inflammation such as the disruption of endothelial-epithelial barriers and adhesion of leukocytes to endothelial cells allowing leukocyte egress into the extracellular space and increasing the leakiness of the endothelial barrier. This is a similar phenomenon with hyeroxia-induced toxicity which is a...

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/). Patients on invasive mechanical ventilation with persistent hypoxemia despite supplemental oxygen (FiO2) usually have significant shunt physiology and/or low cardiac output. If faced with refractory hypoxemia or acute right vent...

BACKGROUND Limited data are available to describe the spectrum of severity of neonatal chronic lung disease. In the multicenter Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity trial, all infants had some degree of pulmonary dysfunction, because eligibility required a median oxygen saturation of < or =94% with room air. Infants randomized to the supplemental oxygen gr...

BACKGROUND Tissue oxygenation is a strong predictor of surgical site infection. Improving tissue oxygenation should thus reduce wound infection risk. Supplemental inspired oxygen can improve tissue oxygenation, but whether it reduces infection risk remains controversial. Low-dose dexamethasone is often given to reduce the risk of postoperative nausea and vomiting, but steroid-induced immunosupp...

Tachypnea and cyanosis in the newborn are frequently encountered problems in the nursery. The incidence of respiratory distress ranges from 2.9% to 7.6%, and 4.3% of newborns may require supplemental oxygen therapy. In this article, the pathophysiology,approach to the diagnosis, and management of clinical conditions are discussed. The physiologic mechanisms involved in the pathogenesis of these...