نتایج جستجو برای: surface display and bacterial pili

تعداد نتایج: 16970276  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Alexandre Persat Yuki F Inclan Joanne N Engel Howard A Stone Zemer Gitai

Bacteria have evolved a wide range of sensing systems to appropriately respond to environmental signals. Here we demonstrate that the opportunistic pathogen Pseudomonas aeruginosa detects contact with surfaces on short timescales using the mechanical activity of its type IV pili, a major surface adhesin. This signal transduction mechanism requires attachment of type IV pili to a solid surface, ...

2017
Longhui Zeng Li Zhang Pengran Wang Guoyu Meng

Pili are critical in host recognition, colonization and biofilm formation during bacterial infection. Here, we report the crystal structures of SafD-dsc and SafD-SafA-SafA (SafDAA-dsc) in Saf pili. Cell adherence assays show that SafD and SafA are both required for host recognition, suggesting a poly-adhesive mechanism for Saf pili. Moreover, the SafDAA-dsc structure, as well as SAXS characteri...

2015
Joseph Gault Mathias Ferber Silke Machata Anne-Flore Imhaus Christian Malosse Arthur Charles-Orszag Corinne Millien Guillaume Bouvier Benjamin Bardiaux Gérard Péhau-Arnaudet Kelly Klinge Isabelle Podglajen Marie Cécile Ploy H. Steven Seifert Michael Nilges Julia Chamot-Rooke Guillaume Duménil Tomoko Kubori

The ability of pathogens to cause disease depends on their aptitude to escape the immune system. Type IV pili are extracellular filamentous virulence factors composed of pilin monomers and frequently expressed by bacterial pathogens. As such they are major targets for the host immune system. In the human pathogen Neisseria meningitidis, strains expressing class I pilins contain a genetic recomb...

Journal: :Journal of bacteriology 2013
Vitold E Galkin Subramaniapillai Kolappan Dixon Ng ZuSheng Zong Juliana Li Xiong Yu Edward H Egelman Lisa Craig

Enterotoxigenic Escherichia coli (ETEC) is a bacterial pathogen that causes diarrhea in children and travelers in developing countries. ETEC adheres to host epithelial cells in the small intestine via a variety of different pili. The CS1 pilus is a prototype for a family of related pili, including the CFA/I pili, present on ETEC and other Gram-negative bacterial pathogens. These pili are assemb...

Journal: :Microbiology 2010
Antoni P A Hendrickx Claudia M E Schapendonk Miranda van Luit-Asbroek Marc J M Bonten Willem van Schaik Rob J L Willems

Pili are hair-like structures protruding from the cell envelope of bacterial cells. Here, we describe the conditional and differential display of PilA-type pili, and PilE and PilF proteins, encoded from pilin gene cluster 1 at the surface of a hospital-acquired Enterococcus faecium bloodstream isolate (E1165) and a community-derived stool isolate (E1039), at two different temperatures. Both str...

Journal: :Journal of bacteriology 2006
Andrew H Gaspar Hung Ton-That

Different surface organelles contribute to specific interactions of a pathogen with host tissues or infectious partners. Multiple pilus gene clusters potentially encoding different surface structures have been identified in several gram-positive bacterial genomes sequenced to date, including actinomycetales, clostridia, corynebacteria, and streptococci. Corynebacterium diphtheriae has been show...

Journal: :Journal of bacteriology 2008
David J VanDyke John Wu Sandy Y M Ng Masaomi Kanbe Bonnie Chaban Shin-Ichi Aizawa Ken F Jarrell

Glycosylation is a posttranslational modification utilized in all three domains of life. Compared to eukaryotic and bacterial systems, knowledge of the archaeal processes involved in glycosylation is limited. Recently, Methanococcus voltae flagellin proteins were found to have an N-linked trisaccharide necessary for proper flagellum assembly. Current analysis by mass spectrometry of Methanococc...

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