Abstract: Aim: Hormone responsive breast cancer is the most prevalent worldwide. Letrozole a third-generation aromatase inhibitor widely used for treatment of advanced cancer. The primary objective present work to develop and optimize an injectable solid lipid nanoparticle incorporating letrozole circumvent side-effects marketed conventional formulation thereby improve patient compliance. Mater...

Poly-(alkylcyanoacrylate) ester particles have been used for the preparation of different formulations ranging from ophthalmic delivery systems to cancer chemotherapy carriers in clinic. The aim of this study was to prepare and characterize poly-(methyl ethyl cyanoacrylate) (PMECA) particles containing 5-aminosalicylic acid (5-ASA). PMECA particles were prepared using the inverse emulsification...

Kencur ( Kaempferia galanga L.) rhizome ethanol extract contains a lipophilic compound of ethyl p-methoxycinnamate. Self-nanoemulsifying drug delivery system (SNEDDS) formulation can increase the solubility in water. The purpose this study was to determine effect surfactant combination on kencur SNEDDS system. formulations were carried out by selecting ratio Tween 80:Span 80 and 80:Chremophor R...

Phenol-soluble modulins (PSMs) are amphipathic peptides produced by staphylococci that have multiple functions in pathogenesis. For example, they may function as cytotoxins and pro-inflammatory agents. Additionally, in a recent study we demonstrated that Staphylococcus aureus PSMs structure biofilms and cause dissemination during biofilm infection. Based on those results suggesting a surfactant...

Objectives: To enhance solubility, dissolution, and permeability of poorly water-soluble drug Ezetimibe (EZE) using a self-nano emulsifying delivery system (SNEDDS). Methods: Initially, the solubility EZE was determined in various oils buffers. Surfactants co-surfactants were screened based on oil as per emulsification efficacy test. Liquid SNEDDS developed characterized. Solid characterized op...

Industrial valorization of proteins from traditional edible insects requires knowledge their nutritional, chemical, technological characteristics. Therefore, these characteristics in two Mexican (A. cordifera and B. mellifica) were studied compared to commercial insect species (H. illucens). The nutritional attributes protein concentrates (PCs) determined by content, amino acid polyphenol compo...

The purpose of preparing Self microemulsifying drug delivery system in this work is to enhance the solubility and oral bioavailability of poorly water soluble drug, Glimepiride. SMEDDS are the isotropic mixture of surfactant, co-surfactant and oil incorporated with drug. In the aqueous media, gastro intestinal motility emulsification takes place. Glimepiride was undergone solubility studies in ...

Biosurfactants are microbial metabolites that may be utilized to replace synthetic chemical surfactant in overcoming the problem of industrial wastewater pollution. Indications presence biosurfactant activity determined through measurement emulsification and enzymatic tested microorganisms on their growth media, which is indicated by decreasing BOD COD media containing material as an inducer ad...

We represent an environmentally friendly sample of pre-treatment method, ultrasound assisted emulsification microextraction (USAEME) followed by gas chromatography nitrogen phosphorous detector (GC-NPD), to specify atrazine residues in environmental samples. Some parameters affecting the extraction efficiency such as the type and volume of the extraction solvent, emulsification time and additio...