method of administering therapeutic agent for their systematic effects such as patient acceptance, convenience in administration, and cost-effective manufacturing process. Thus, a wide variety of approaches of drug delivery system (DDS) have been investigated for oral application. However, the development process is precluded by several physiological difficulties, such as an inability to restra...

The importance of the present investigation was to formulate a bilayer-floating tablet (BFT) for captopril using direct compression technology. The release layer contained captopril and various polymers such as HPMC-K15M, PVP-K30 and Carbopol 934p, alone or in combination with the drug. HPMC, K-grade and effervescent mixture of citric acid and sodium bicarbonate formed the floating layer. The f...

A new strategy is proposed for the triple drug treatment (tetracycline, metronidazole and bismuth salt) of Helicobacter pylori associated peptic ulcers. The design of the delivery system was based on the swellable asymmetric triple layer tablet approach, with floating feature in order to prolong the gastric retention time of the delivery system. Hydroxypropylmethylcellulose and poly(ethylene ox...

Abstract: Objectives: Stavudine has a low half-life of 0.8-1.5 hr and therefore needs recurrent administration to sustain stable beneficial drug plasma levels. In order enhance preserve the level stavudine for round clock, gastroretentive systems (floating low-density formulations that cause buoyancy on gastric fluid in stomach) may prove be advantageous releasing content from matrix tablet res...

The overall objective of the present work was to develop an oral sustained-release (SR) Metformin tablet that is prepared by direct compression method using hydrophilic hydroxyl propyl methyl cellulose (HPMC) and Guar gum polymer alone as well in combination at different concentrations. a biguanide has relatively short plasma half-life. It low absolute bioavailability. All properties were evalu...

Sustained release tablets of Diclofenac Sodium were fabricated using Cashew nut tree gum, HPMC and Carbopol . The tablets were evaluated for preformulation studies like angle of repose, bluk density, compressibility index and physical characteristics like hardness, weight variation, fraibilty and drug content. In-vitro release of drug was performed in PBS pH 7.2 for twelve hours. All the physic...

Migraine follows circadian rhythm in which headache is more painful at the awakening time. This needs administration of dosage form at night time to release drug after lag period when pain gets worse. Sumatriptan succinate is a drug of choice for migraine. Sumatriptan succinate has bitter taste, low oral bioavailability, and shorter half-life. Present work deals with application of design of ex...

Cefdinir (Cef) is a third-generation cephalosporin antibacterial agent with an extended spectrum and low solubility permeability. In this study, cefdinir was prepared as nanosuspension lyophilized to powder. The further processed develop bilayer tablet. By utilizing the approach, first therapeutic action impacted by immediate part's rapid disintegration prolonged release from floating part achi...