BACKGROUND Desvenlafaxine is used as an antidepressant and acts by inhibiting reuptake of serotonin and nor-adrenaline. PURPOSE The safety profile of desvenlafaxine has not yet been established during pregnancy, so we planned this study to see the behavioral changes in pups of mice who received desvenlafaxine during gestational period. METHODS Swiss albino mice were used for the present stu...

β-Cyfluthrin, is a broad-spectrum type II synthetic pyrethroid insecticide. People are exposed to cyfluthrin by consuming contaminated food and from residues persisting after indoor or outdoor applications of cyfluthrin containing products. The aim of this study was to evaluate the neurobehavioral toxicity of cyfluthrin after oral administration to Swiss albino mice. Male weanlings (21 days old...

This study compared PCR and Western blot techniques in diagnosis of schistosomiasis mansoni. Forty Swiss albino mice were used, thirty two mice were infected with cercariae of S. mansoni and eight mice were kept uninfected which were used as a control. Blood was obtained from four infected mice weekly beginning from the 1st week to the 8th week post infection. The study found that PCR was posit...

BACKGROUND It is known that following chronic dosing with bupropion HCl active metabolites are present in plasma at levels that are several times higher than that of the parent drug, but the possible convulsive effects of the major metabolites are not known. METHODS We investigated the convulsive liability and dose-response of the three major bupropion metabolites following intraperitoneal ad...

Nutmeg, the dried seed kernel of Myristica fragrans, MF (Family: Myristicaceae) possesses antifungal, hepatoprotective and antioxidant properties. Its radioprotective effect against 6, 8 and 10 Gy gamma radiation was evaluated by 30 day survival assay. Regression analysis yielded LD(50/30 )as 6.83 Gy and 8.89 Gy for irradiated only and (MF + radiation) groups, respectively. The dose reduction f...

Aim: To ascertain the maximum tolerated dose (MTD) and to investigate the acute oral toxic effects of imidacloprid towards Swiss albino male mice. Materials and Methods: The MTD of imidacloprid was determined in pilot dose range finding study following the standard method. Animals were observed for toxic signs and symptoms after oral administration of MTD of imidacloprid in single dose. th The ...