INTRODUCTION Osteoarthritis (OA) is a degenerative disease characterized by cartilage breakdown in the synovial joints. The presence of low-grade inflammation in OA joints is receiving increasing attention, with synovitis shown to be present even in the early stages of the disease. How the synovial inflammation arises is unclear, but proteins in the synovial fluid of affected joints could conce...

Vitamin B12 levels and its binding capacity in the synovial fluid of the patients with joint diseases have been investigated, and the presence of vitamin B12 and its binding capacity in the synovial fluid have been demonstrated. Synovial B12 levels in the patients with rheumatoid arthritis were much lower than those in osteoarthritis, whereas B12 binding capacity in the synovial fluid of rheuma...

A method of synovial fluid preparation giving optimal hydroxyapatite detection as well as definitions of the threshold masses of hydroxyapatite in viscous synovial fluid detectable by x ray diffraction and scanning electron microscopy with energy dispersive analysis is reported. Use of an equal volume of 100% hydrazine with the synovial fluid optimised detection of hydroxyapatite. By x ray diff...

The purpose of this study was to investigate the comparative diagnostic strength of C-reactive protein (CRP) values in synovial fluid and serum in patients with presumed periprosthetic joint infection. We collected 44 synovial fluid samples and 24 serum samples from 43 patients. Patients were judged to be uninfected or infected based on standardized criteria. Synovial and serum samples were obt...

Synovial fluid is not a static pool, but is continually being absorbed and replenished by the synovial lining of the joint cavity (synovium, synovial intima), which is approximately 20 ,m thick (rabbit knee) to approximately 60 pm thick (human knee). The three key elements for fluid turnover are the synovial capillary, synovial interstitium, and the lymphatic drainage system. Synovial capillari...

Methods The concentrations of SP-A, SP-D, CRP, IgA, IgM, IgG, and rheumatoid factor were measured in the synovial fluid of 7 patients with rheumatoid arthritis and 3 samples of healthy synovial fluid obtained at autopsy. The bands obtained by specific antibodies in Western blotting to determine the surfactant protein concentration were analyzed densitometrically and synovial fluid total phospho...

rheumatoid factors (rf) are autoantibodies with specificity for the fc portion of human igg. production of rf is a characteristic feature of rheumatoid arthritis (ra) and is detectable in high titer in about 90% of these patients. in this study, we measured total igm, iga, igmrf and igarf in serum and synovial fluid of 45 ra patients by elisa and the results were compared with those obtained by...

In many inflammatory disorders excess iron is found within reticuloendothelial cells. In patients with rheumatoid arthritis the synovial membrane contains an excess of iron (in the form of ferritin) concentrated within the cytoplasm and lysosomes of the type A reticuloendothelial cells.1 The concept that this iron may promote or worsen inflammation is not new. de Duve2 suggested that lysosomes ...

In many inflammatory disorders excess iron is found within reticuloendothelial cells. In patients with rheumatoid arthritis the synovial membrane contains an excess of iron (in the form of ferritin) concentrated within the cytoplasm and lysosomes of the type A reticuloendothelial cells.1 The concept that this iron may promote or worsen inflammation is not new. de Duve2 suggested that lysosomes ...

Background: Progenitor cells exist in most tissues and body fluids. Synovial fluid chondroprogenitor cells have been described in several species; however, the specific phenotypic characteristics of these cells have not been defined. This study addressed the impacts of joint location and donor age variation on synovial fluid chondroprogenitor numbers, and determined whether synovial fluid chond...