Poorly differentiated synovial sarcomas are diagnostically challenging soft tissue tumors. They can be indistinguishable from other "small blue cell tumors" based on morphology and even immunohistochemical studies. Here we report a rare case of poorly differentiated metastatic synovial sarcoma to lung without known primary, diagnosed with molecular genetic analysis. The tumor was negative for E...

Background: Intraosseous Synovial Sarcoma is extremely rare. To the author’s knowledge this is the first description of an intraosseous synovial sarcoma of the scapula. Case description: Here, a case of a giant Synovial Sarcoma of the body of the scapula is reported. Diagnosis was based on histologic (haematoxylin and eosin) pattern and immunohistochemical analysis and confirmed by cytogenetics...

Synovial sarcoma is a primitive mesenchymal neoplasm characterized in almost all cases by a t(X;18) fusing the SYT transcriptional coactivator gene with either SSX1 or SSX2, with the resulting fusion gene encoding an aberrant transcriptional regulator. A subset of synovial sarcoma, predominantly cases with the SYT-SSX1 fusion, shows foci of morphologic epithelial differentiation in the form of ...

To investigate the effects of anchor substitutions in SYT-SSX junction peptide, an HLA-A24 anchor residue (position 9) of the SYT-SSX B peptide (GYDQIMPKK) was substituted to more favorable residues according to the HLA-A24-binding motif. Among four substitutes constructed, a substitute with isoleucine (termed K9I peptide) most apparently enhanced the affinity for HLA-A24 molecule. Subsequent i...

here, we describe young men with synovial sarcoma in the palatine tonsil, who presented with a 3-4 month history of progressive sore throat, tonsillar ulcerative mass and bleeding. clinical and radiological examinations revealed that the tumors arose from the palatine tonsil and extended to the parapharyngeal space. both tumors were too advanced to remove completely; therefore, they underwent s...

Synovial sarcomas are a rare entity with predilection for extremities and joints. The literature suggests that these tumours are rare in the head and neck region. Very few authors have reported their origin in head. Among the ones occurring in the head region, most of them are found to originate from the parotid area. According to our extensive review of available literature, there has been no ...

Synovial sarcoma is defined as a mesenchymal spindle cell tumour which displays variable epithelial differentiation including glandular formation and has a specific chromosomal translocation [1]. It is an aggressive and rare neoplasm which is histologically classified into two subtypes: monophasic and biphasic. Epithelial predominant synovial sarcoma can mimic epithelial neoplasms and is freque...

A 17 year old Malay student who is a known case of synovial sarcoma of left elbow (treated with an above elbow amputation) presented with duodenal obstruction. We report an unusual case of gastrointestinal tract metastases from synovial sarcoma. To our knowledge, there is no previous such report in the literature. The computed tomography (CT) and magnetic resonance imaging (MRI) features are de...