The effect of a protein-free diet and starvation on the duration of the rat ileal crypt cell cycle time was studied by Quastler's technique of labeled mitoses. Rats were fed a protein-free diet for 3, 7, or 11 wk or were starved for 7 or 10 days. Progressive protein depletion resulted in a progressive lengthening of the cycle time (GT), due primarily to a lengthening of the synthetic phase (S) ...

Obesity has reached pandemic levels worldwide. The current models of diet-induced obesity in rodents use predominantly high-fat based diets that do not take into account the consumption of variety of highly palatable, energy-dense foods that are prevalent in Western society. We and others have shown that the cafeteria (CAF) diet is a robust and reproducible model of human metabolic syndrome wit...

Polyamines are thought to be involved in the regulation of numerous metabolic and electrophysiological processes in the nervous system. In this study we evaluated the effect of a synthetic polyamine-deficient diet on pain in a carrageenan (Car)-induced inflammatory rat model. Inflammation was induced with a unilateral subcutaneous injection of Car in a plantar hindpaw in rats fed without (contr...

BACKGROUND We have previously shown that dietary iron restriction prevents the development of renal damage in a rat model of chronic kidney disease (CKD). However, iron deficiency is associated with appetite loss. In addition, calorie restriction is reported to prevent the development of end-stage renal pathology in CKD rats. Thus, the beneficial effect of iron restriction on renal damage may d...

BACKGROUND The conjugated linoleic acid (CLA) content of beef can be increased by supplementing appropriate beef cattle diets with vegetable oil or oil seed. Yet the effect of consumption of such beef on adipose tissue characteristics is unclear, thus the study was conducted to compare adipose tissue responses of rats to diets containing beef from steers either not provided or provided the oil ...

BACKGROUND: Coffee arabica gayo leaf extract (Coffea L.) contains polyphenols (chlorogenic acid), flavonoids, saponins, tannins, and steroids which improved PI3K serum levels in rats type 2 diabetic rat. AIM: The purpose of the study was to determine effect Arabica Gayo Leaf Extract (C. on increased type-2 rat (Rattus norvegicus). METHODS: Thirty-five male Wistar with induced a combination feed...

Endurance exercise training enhances muscle fat oxidation while concomitantly reducing carbohydrate (glycogen) utilization during exercise, thereby delaying the onset of fatigue. This study examined effects dietary restriction on endurance training-induced metabolic adaptations in rat skeletal muscle. Male Sprague-Dawley rats were placed either a control diet (CON: 19.2% protein, 21.6% fat, and...

Thiosulfonates are characterized by a wide spectrum of biological activity and have effective antimicrobial, antithrombotic, antitumor antiparasitic effects. However, the use synthetic sulfur-containing compounds for therapeutic preventive purposes requires study their effect on protective mechanisms maintaining homeostasis, antioxidant status body in particular. The aim was to estimate lipid p...