Abstract Introduction Because of the activities and effects they induce, hormones are prohibited for use anabolic purposes in farm animals intended slaughter, which is regulated European Union by relevant legal provisions. Therefore, there an obligation to monitor residues food animal origin ensure consumer safety. A hormone banned but used formerly fattening cattle, stanozolol, its metabolite ...

Recent efforts have focused on identifying small nonpeptide molecules that can mimic the activity of endogenous peptide hormones. Understanding the molecular basis of ligand-induced receptor activation by these divergent classes of ligands should expedite the process of drug development. Using the cholecystokinin-B/gastrin receptor (CCK-BR) as a model system, we have recently shown that both af...

Endocrine-disrupting chemicals (EDCs) are natural or synthetic substances able to mimic, interfere with, block endogenous hormones, thus disrupting the normal function of endocrine system. Most them largely applied in agriculture and industry. As a result, humans chronically exposed mixtures EDCs. Their adverse effect on human health may appear long after exposure, making it difficult assess th...

BACKGROUND In recent years, endocrine disrupting compounds (EDCs) have been found in rivers that receive significant inputs of wastewater. Among EDCs, natural and synthetic steroid hormones are recognized for their potential to mimic or interfere with normal hormonal functions (development, growth and reproduction), even at ultratrace levels (ng L(-1)). Although conjugated hormones are less act...

RATIONALE Estuaries are dynamic ecosystems, providing vital habitat for unique organisms of great ecological and commercial importance. The influx of natural and synthetic steroid hormones into estuaries poses risks to these organisms and to broader ecosystem health. However, detecting these trace level pollutants in estuarine water and sediment requires improved analytical techniques. METHOD...

Responses to endocrine active substances (EASs) in animals are various, and differences between the responses among individuals, populations, and species are well known. These differences are observed not only in EASs but in most environmental chemicals including synthetic and naturally occurring ones. The basic differences in sensitivity to EASs are attributed to that of affinity or specificit...

background: endometrial remodeling occurs during each menstrual cycle in women. reports have shown that, in a variety of cell types, processes such as proliferation, signaling complex formation and extra cellular matrix remodeling require a cytoplasmic tyrosine kinase, focal adhesion kinase (fak). the present study has focused on the expression pattern of fak in human endometrium during the men...

multiple sclerosis is a chronic inflammatory disease of central nervous system.women are more susceptible to this disease. one of the obvious clinical complaints in women with multiple sclerosis specially treated with beta interferones is menstrual cycle irregularity. the aim of this study was to determine the prevalence of menstrual irregularities and probable changes in blood levels of relate...

objective(s): the adverse effects of pyridaben on reproductive system in male animals are not well established. this study was designed to elucidate how pyridaben can effects the histomorphometric, hormonal alternations and reproductive functions of balb/c mice .   materials and methods : for this study, 80 adult and apparently healthy male balb/c mice were divided into three groups viz, contro...

objective in this study, we investigated the changes of the serum levels of thyroidhormones including thyroxine (t4), triiodothyronine (t3), t3 resin uptake andthyroid stimulating hormone (tsh) in epileptic children during treatment withanti-epileptic drugs (aeds) including carbamazepine (cbz), primidone (prm),phenobarbital and valproic acid (vpa). materials and methods this study consisted of ...