White matter fiber tracts demonstrate heterogeneous vulnerabilities to aging effects. Here, we estimated age-related differences in tract properties using UK Biobank diffusion magnetic resonance imaging data of 7167 47- 76-year-old neurologically healthy people (3368 men and 3799 women). Tract terms generalized fractional anisotropy, axial diffusivity, radial mean diffusivity were sampled on 76...

We estimate the impact of Community Reinvestment Act (CRA) on small business lending in lower-income neighborhoods. Using 2004-2016 panel data census tracts, we apply a combined regression discontinuity and fixed effect method. find that number loans increases by about 3 to 4 percent total dollar amount 6 10 tracts becoming treated CRA. The results are robust along many dimensions suggest CRA h...

Healthy human brain development is a complex process that continues during childhood and adolescence, as demonstrated by many cross-sectional and several longitudinal studies. However, whether these changes end in adolescence is not clear. We examined longitudinal white matter maturation using diffusion tensor tractography in 103 healthy subjects aged 5-32 years; each volunteer was scanned at l...

PURPOSE The purpose of this study was to compare the deterministic and probabilistic tracking methods of diffusion tensor white matter fiber tractography in patients with brain tumors. MATERIALS AND METHODS We identified 29 patients with left brain tumors <2 cm from the arcuate fasciculus who underwent pre-operative language fMRI and DTI. The arcuate fasciculus was reconstructed using a deter...

In many applications of Geographical Information Systems (GIS) a common task is the conversion of addresses into grid coordinates. In many countries this is usually accomplished using address range TIGER-type Ž les in conjunction with geocoding packages within a GIS. Improvements in GIS functionality and the storage capacity of large databases mean that the spatial investigation of data at the ...

Although many low-income urban areas are highly walkable by conventional measures such as population density or land use mix, chronic diseases related to lack of physical activity are more common among residents of these areas. Disparities in neighborhood conditions may make poor areas less attractive environments for walking, offsetting the advantages of density and land use mix. This study co...

Triplex structure-forming GAA/TTC repeats pose a dual threat to the eukaryotic genome integrity. Their potential to expand can lead to gene inactivation, the cause of Friedreich's ataxia disease in humans. In model systems, long GAA/TTC tracts also act as chromosomal fragile sites that can trigger gross chromosomal rearrangements. The mechanisms that regulate the metabolism of GAA/TTC repeats a...