نتایج جستجو برای: t cell leukemia
تعداد نتایج: 2243405 فیلتر نتایج به سال:
Patient outcomes in T-cell acute lymphoblastic leukemia and lymphoma (T-ALL/LBL) can be difficult to predict. Simonin et al report deletions mutations the gene encoding transcription factor IKAROS among 1260 children adults with immature T-ALL/LBL, defining its frequency and, importantly, association poor outcome multivariate models. Pathogenic alterations IKZF1 now added minimal residual disea...
The importance of microenvironmental factors for driving progression in leukemia has been debated. Previous evidence has pointed to interleukin-7 (IL-7), a fundamental cytokine to normal T-cell development and homeostasis, as an important determinant of the viability and proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells in vitro. In this study, we report that IL-7 is also a cri...
introduction: laser phototherapy is used for the treatment of chemotherapy-induced oral mucositis in patients with leukemia, although there are limited data supporting the safety of this method. this study aimed to evaluate the effect of different doses of low-level laser on proliferation of acute myeloid leukemia (aml) cell line (kg-1a) in vitro. methods: a plastic flask containing 5,000,000 k...
conclusions in iran, hsct has been successfully adapted in routine clinical care. recently, new methods such as double cord blood and haploidentical transplantation have been used to treat many life-threatening diseases. results about 78.2% of the patients (2530 of 3237) remained alive between one to 211 months after stem cell transplantation. nearly, 21.8% (707) of our patients died after stem...
T cell acute lymphoblastic leukemia (T-ALL) develops through accumulation of multiple genomic alterations within T-cell progenitors resulting in clonal heterogeneity among leukemic cells. Human T-ALL xeno-transplantation in immunodeficient mice is a gold standard approach to study leukemia biology and we recently uncovered that the leukemia development is more or less rapid depending on T-ALL s...
Objective: Lymphoid enhancer-binding factor-1 (LEF1) is one of the key regulators lymphocyte proliferation and its aberrant expression a prognostic factor for lymphoid or myeloid malignancies. In this study, we focused on LEF1 isoforms in several hematological malignancies found tissue-specific differential full-length (FL)-LEF1 gene tumor suppressor (∆LEF1) variant. Material Method: Fifty-thre...
The importance of microenvironmental factors for driving progression in leukemia has been debated. Previous evidence has pointed to interleukin-7 (IL-7), a fundamental cytokine to normal T-cell development and homeostasis, as an important determinant of the viability and proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells in vitro. In this study, we report that IL-7 is also a cri...
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