نتایج جستجو برای: t follicular helper cells tfh cells

تعداد نتایج: 1928608  

2018
Elliot T Byford Matthew Carr Eleni Ladikou Matthew J Ahearne Simon D Wagner

CD4+ T-cell subsets are found in the tumour microenvironment (TME) of low-grade B-cell non-Hodgkin's lymphomas such as marginal zone lymphoma (MZL) or follicular lymphoma (FL). Both numbers and architecture of activating follicular helper T-cells (Tfh) and suppressive Treg in the TME of FL are associated with clinical outcomes. There has been almost no previous work on CD4+ T-cells in MZL. It i...

2016
Dennis Stauss Cornelia Brunner Friederike Berberich‐Siebelt Uta E Höpken Martin Lipp Gerd Müller

Follicular T helper (Tfh) cells are key regulators of the germinal center reaction and long-term humoral immunity. Tfh cell differentiation requires the sustained expression of the transcriptional repressor Bcl6; however, its regulation in CD4(+)T cells is incompletely understood. Here, we report that the transcriptional coactivator Bob1, encoded by thePou2af1gene, promotes Bcl6 expression and ...

Journal: :Journal of immunology 2013
Youn Soo Choi Danelle Eto Jessica A Yang Christopher Lao Shane Crotty

Bcl6 is required for CD4 T cell differentiation into T follicular helper cells (Tfh). In this study, we examined the role of IL-6 in early processes of in vivo Tfh differentiation, because the timing and mechanism of action of IL-6 in Tfh differentiation have been controversial in vivo. We found that early Bcl6(+)CXCR5(+) Tfh differentiation was severely impaired in the absence of IL-6; however...

2016
Hao Wu Markus M. Xie Hong Liu Alexander L. Dent

The production of antibody is precisely controlled during the germinal center (GC) reaction. This process is dependent on the help from follicular T helper (Tfh) cells to germinal center (GC) B cells and is regulated by regulatory follicular T helper (Tfr) cells. How Tfr cells develop and how their suppressive activity functions are not well understood. Here, we found that Stat3 is indispensibl...

Journal: :Journal of immunology 2015
Hao Wu Lin-Lin Xu Paulla Teuscher Hong Liu Mark H Kaplan Alexander L Dent

The transcription factor Bcl6 is required for development of follicular helper T (TFH) cells. Cytokines that activate Stat3 promote Bcl6 expression and TFH cell differentiation. Previous studies with an acute virus infection model showed that TFH cell differentiation was decreased but not blocked in the absence of Stat3. In this study, we further analyzed the role of Stat3 in TFH cells. In Peye...

2013
Jingyao Zhang Wenjuan Gao Qirui Guo Bobo Huang Bin Wang Guoliang Xia Youmin Kang

Protein vaccines combined with adjuvants have been widely used to induce immune responses, especially the humoral immune response, against molecular targets including parasites. Follicular T helper (Tfh) cells are the specialized providers of B-cell help, however, the induction of Tfh cells in protein vaccination has been rarely studied. Here, we report that the Schistosoma japonicum recombinan...

2017
Xiaojuan Ma Zhan Sun Pei Zhai Wenyan Yu Ting Wang Fengsen Li Jianbing Ding

Follicular helper T (TFH) cells are considered to be a separate T helper cell subset, specifically to help memory B cell participate in humoral immunity. It has been reported that there is an association between the imbalance of TFH function and certain autoimmune diseases. However, to the best of our knowledge, the effect of TFH cells on the process of bronchial asthma has not been investigate...

Journal: :Journal of immunology 2015
Ankita Chowdhury Perla Mariana Del Rio Estrada Greg K Tharp Ronald P Trible Rama R Amara Ann Chahroudi Gustavo Reyes-Teran Steven E Bosinger Guido Silvestri

T follicular helper cells (TFH) are critical for the development and maintenance of germinal center (GC) and humoral immune responses. During chronic HIV/SIV infection, TFH accumulate, possibly as a result of Ag persistence. The HIV/SIV-associated TFH expansion may also reflect lack of regulation by suppressive follicular regulatory CD4(+) T cells (TFR). TFR are natural regulatory T cells (TREG...

Journal: :Journal of Immunology 2021

Abstract The activation of T cells is accompanied by intensive posttranscriptional remodeling their proteome. We observed that protein expression enzymes modify wobble uridine in specific tRNAs, namely elongator subunit 3 (Elp3) and cytosolic thiouridylase (Ctu)2, increased the course cell activation. To investigate role these tRNA epitranscriptomic modifiers biology, we generated mice deficien...

2015
Konstantia-Maria Chavele Eve Merry Michael R. Ehrenstein

B cells require CD4(+) T follicular helper (Tfh) cells to progress through the germinal center and provide protective Ab responses. In this article, we reveal a reciprocal interaction whereby circulating human plasmablasts are potent inducers of the Tfh cell-differentiation program, including the expression of their key transcription factor Bcl-6. The markedly increased propensity of plasmablas...

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