Abstract Funding Acknowledgements Type of funding sources: None. Background The world’s population is ageing: every country experiencing growth in both the size and proportion older people. Common health states age mainly include cardiovascular disease. To ensure that our system ready to face this demographic shift, we investigated native post-contrast T1 mapping as a quantitative method apprai...

PURPOSE To determine whether magnetization transfer imaging can improve visibility of contrast enhancement of multiple sclerosis plaques. METHODS Fifty-nine enhancing and 63 nonenhancing lesions in 10 patients with multiple sclerosis were evaluated to calculate contrast-to-noise ratios on conventional T1-weighted and T1-weighted magnetization transfer images. The signal intensity of the lesio...

Background Native myocardial T1 mapping with CMR has emerged as a new diagnostic tool in heart disease. However, myocardial T1 will be affected by the T1 of blood present in the myocardium. To explore this, as there is no easy way to manipulate blood in isolation, we hypothesized that the population standard deviation (SD) for myocardial T1 could be reduced by correcting the myocardial T1 for c...

Background SMART1Map is a new single-point technique for cardiac T1 mapping [1]. Unlike Look-Locker approaches, such as MOLLI, which yield an “apparent” T1 (T1*), SMART1Map directly measures true T1. Because T1* is a function of imaging parameters, it is always shorter than T1, and correction methods are required to obtain the true T1. This work compared the accuracy of SMART1Map with MOLLI in ...

BACKGROUND T1-mapping using the Shortened Modified Look-Locker Inversion Recovery (ShMOLLI) technique enables non-invasive assessment of important myocardial tissue characteristics. However, tachyarrhythmia may cause mistriggering and inaccurate T1 estimation. We set out to test whether systolic T1-mapping might overcome this, and whether T1 values or data quality would be significantly differe...

Background MOLLI [1] uses interleaved Look-Locker (LL) blocks for cardiac T1 mapping. Data is fit to the equation A-Bexp (-TI/T1*) to yield an “apparent” T1 (T1*), which is dependent on both the true T1 and imaging parameters. To estimate true T1, a “LL correction” T1est=(B/A-1) T1* [Eq. 1] has been proposed [1,2]. Although this correction can provide reasonable estimates of true T1, we are not...