Traditional spectral-based methods such as PCA are popular for anomaly detection in a variety of problems and domains. However, if data includes tensor (multiway) structure (e.g. space-time-measurements), some meaningful anomalies may remain invisible with these methods. Although tensor-based anomaly detection (TAD) has been applied within a variety of disciplines over the last twenty years, it...

The purpose of this paper is to introduce the use of an object-oriented methodology called TAD in the field of business process reengineering. TAD methodology consists of six phases and uses several tables to represent the real world of the enterprise. The first and second phases deal with identifying the reality of the system. The third phase focuses on carrying out business process reengineer...

BACKGROUND Here we investigated Brahma-related gene 1 (BRG1) expression in aortic smooth muscle cells (SMCs) and its role in the regulation of the pathological changes in aortic SMCs of thoracic arotic dissection (TAD). METHODS BRG1, matrix metalloproteinase 2 (MMP2), and MMP9 mRNA and protein expression in human aortic specimens were examined by qPCR and western blot, respectively. The perce...

OBJECTIVES To review the literature in order to estimate how many previously unknown thoracic aortic aneurysms (TAAs) and thoracic aortic dilatations (TADs) might be detected by systematic, cross-sectional aortic imaging of patients with giant cell arteritis (GCA). METHODS A systematic literature review was performed using Ovid Medline, Embase and the Cochrane Library. Studies potentially rel...

Abstract Genome organization is driven by forces affecting transcriptional state, but the relationship between transcription and genome architecture remains unclear. Here, we identified Drosophila factor Motif 1 Binding Protein (M1BP) in physical association with gypsy chromatin insulator core complex, including universal protein CP190. M1BP required for enhancer-blocking barrier activities of ...

Induction of gene expression by the papillomavirus E2 protein requires its approximately 220-amino-acid amino-terminal transactivation domain (TAD) to interact with cellular factors that lead to formation of an activated RNA polymerase complex. These interaction partners have yet to be identified and characterized. The E2 protein localizes the transcription complex to the target promoter throug...

Increasing evidence in the last years indicates that the vast amount of regulatory information contained in mammalian genomes is organized in precise 3D chromatin structures. However, the impact of this spatial chromatin organization on gene expression and its degree of evolutionary conservation is still poorly understood. The Six homeobox genes are essential developmental regulators organized ...

BACKGROUND Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population. METHODS In our case-control study, we recruited 755 unrelated participants: 315 case participants with TAD and 440 controls. Twenty-two tag SNPs ...

Post-transcriptional gene silencing (PTGS) involving small interfering RNA (siRNA)-directed degradation of RNA transcripts and transcriptional silencing via DNA methylation have each been proposed as mechanisms of genome defence against invading nucleic acids, such as transposons and viruses. Furthermore, recent data from plants indicates that many transposons are silenced via a combination of ...

Natural transformation has been described in bacterial species spread through nearly all major taxonomic groups. However, the current understanding of the structural components and the regulation of competence development is derived from only a few model organisms. Although natural transformation was discovered in members of the Actinobacteria (high GC Gram-positive bacteria) more than four dec...