BACKGROUND Fungal laccase has profound applications in different fields of biotechnology due to its broad specificity and high redox potential. Any successful application of the enzyme requires large scale production. As laccase production is highly dependent on medium components and cultural conditions, optimization of the same is essential for efficient product production. RESULTS Productio...

In general, the optimization problems contain more than one response, which often conflict with each other. This paper proposes the TOPSIS-based Taguchi optimization approach to determine the optimization of reverse osmosis process parameters for improving recovery and quality of permeate. The performance criteria are identified for Permeate are COD, Total Solids, Conductivity and Hardness in r...

background: enzymatic hydrolysis of lactose is one of the most important biotechnological processes in the food industry, which is accomplished by enzyme β-galactosidase (β-gal, β-d-galactoside galactohydrolase, ec 3.2.1.23), trivial called lactase. orthogonal arrays design is an appropriate option for the optimization of biotechnological processes for the production of microbial enzymes. metho...

The process of material cutting and fracture by high velocity water jets is a complex series of phenomena which may involve compression, tension, shear, erosion, wears, cracking, wave propagation, and cavitations damage. This makes the exact analysis of the jet cutting process to be very complicated. The problem of water jet coal cutting is a multiresponse problem. There are two output variable...

Optimization for enhanced phytase production by Aspergillus oryzae SBS50 in submerged fermentation was investigated using Taguchi design. In first step design, starch, beef extract, magnesium sulphate, ferrous sulphate and Tween 80 were identified as significant factors affecting phytase production. These significant factors were further optimized at four different levels using a second Taguchi...

Wire Electrical Discharge Machining (WEDM) is a non-traditional thermo-electric process capable of machining hard materials of highly complex three dimensional shapes. In this paper, the dry WEDM experimentation is conducted using oxygen as a dielectric medium. The deionized water is replaced by the oxygen as a dielectric medium to ameliorate the environmental impact in the machining surroundin...

The Mahalanobis Taguchi System (MTS) is considered one of the most promising binary classification algorithms to handle imbalance data. Unfortunately, MTS lacks a method for determining an efficient threshold for the binary classification. In this paper, a nonlinear optimization model is formulated based on minimizing the distance between MTS Receiver Operating Characteristics (ROC) curve and t...

Implementing CIM (Computer Integrated Manufacturing) often requires models of manufacturing processes to be devised for determining optimal process parameters and designing adaptive control systems. Despite the progress made in analytical (mechanistic) modeling, however, empirical models derived from experimental data are more frequently used in practice. This paper describes the development of...