The central mechanisms through which MDMA mediates life-threatening hyperthermia when taken in a warm environment are not well described. It is assumed that MDMA alters normal thermoregulatory circuits resulting in increased heat production through interscapular brown adipose tissue (iBAT) and decreased heat dissipation through cutaneous vasoconstriction. We studied the role of the dorsomedial ...

Recent studies have reported that massive rotator cuff tears do not heal as predictably as, and may have diminished clinical outcomes compared with, smaller rotator cuff tears. An improved understanding of the biologic degeneration and the biomechanical alterations of massive rotator cuff tears should provide better strategies to optimize outcomes. The approach to patients with massive rotator ...

results bw was lower for the 5/6 nx group rats after the operations compared with the bw of those in the sham operation group. furthermore, the 5/6 nx group showed elevations in blood pressure, cr, bun, alt, and ast levels compared with the sham group over the course of time. conclusions in summary, ckd induced by the 5/6 nx model caused hypertension and increased serum levels of cr, bun, alt, ...

This study examines the relationship between pneumatic tourniquet cuff size, occlusion pressure and the resulting pain. Two tourniquet cuff widths were used, a wide (14 cm) and a narrow cuff (7 cm). Twenty volunteers were divided into two groups for tourniquet application: a pressure group in which the tourniquet was inflated to a pressure equal to the systolic pressure + 100 mmHg, and a satura...

We studied the effect of deflating the laryngeal mask airway (LMA) cuff in situ on recorded respiratory tidal ventilation in 30 spontaneously breathing anaesthetized patients. Another 26 patients were studied in whom the LMA cuff was undisturbed. Deflation of the cuff to a pressure of 22 mm Hg (below an estimated arteriolar perfusion pressure of the pharyngeal mucosa), by removing approximately...

Background: It is unknown whether measuring endotracheal tube cuff pressure can accurately confirm tracheal intubation. Animal and human cadaveric studies show conflicting results. In anesthetized patients, we tested the hypothesis that the pressurevolume characteristics of the cuff located in the trachea would differ from that measured in the esophagus potentially making cuff pressure a useful...

Historically, many causes have been proposed for rotator cuff conditions. The most prevalent theory is that the rotator cuff tendons, especially the supraspinatus, make contact with the acromion and coracoacromial ligament, resulting in pain and eventual tearing of the tendon. However, more recent evidence suggests that this concept does not explain the changes in rotator cuff tendons with age....

The rotator cuff provides dynamic stability and is critical to normal shoulder function. Forces generated by the rotator cuff facilitate the motions involved in activities of daily living and the more demanding movements of athletics and manual labor. Injury and pathology of the rotator cuff are common and the unique anatomical and biomechanical characteristics of the cuff contribute to the eti...

We present our technique in managing high-grade bursal-sided rotator cuff tears. In this technique, the remaining intact cuff tissue is not sacrificed. The suture bridge technique is used to uniformly tension the torn tissue to the rotator cuff footprint. No knots are tied on the rotator cuff to minimize the tension on the cuff. The sutures are then anchored on the lateral cortex of the humerus...

Strangulation around cuff tissue is a possible cause of retear after rotator cuff repair. Therefore, tendon healing ideally requires changes in suture tension over the cuff tissue in accord with rotator cuff muscle activity. The authors present a type of fixation that mimics the mechanism of the Chinese finger trap. The devised knot-free tendon trap technique resembles the double-pulley-suture ...