Kinins are potent inflammatory mediators, liberated from kininogens by different kininogenases. The aim of this study was to investigate the kinin generation pathways in acute and chronic inflammation of the lower airways. We studied bronchoalveolar lavage fluid (BALF) of patients with acute pneumonia, patients with chronic bronchitis and healthy controls. Kinins were determined by radioimmunoa...

We investigate the canonicity of inequalities of the intuitionistic mu-calculus. The notion of canonicity in the presence of fixed point operators is not entirely straightforward. In the algebraic setting of canonical extensions we examine both the usual notion of canonicity and what we will call tame canonicity. This latter concept has previously been investigated for the classical mu-calculus...

Effect of genistein, a protein tyrosine kinase inhibitor, on TAME-esterase induced contractions were studied on rat aorta strips in vitro. Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were pre-incubated with genistein. The present findings provide evidence for the possible contribution ...

Every tame, prime and alternating knot is equivalent to a tame, prime and alternating knot in regular position, with a common projection. In this work, we show that the Dehn presentation of the knot group of a tame, prime, alternating knot, with a regular and common projection has a finite and complete rewriting system. Although there are rules in the rewriting system with lefthand side a gener...

Neoadjuvant chemotherapy has practical and theoretical advantages over adjuvant chemotherapy strategy in breast cancer (BC) management. Moreover, metronomic delivery has a more favorable toxicity profile. The present study examined the feasibility of neoadjuvant metronomic chemotherapy in two cohorts [HER2+ (TraQme) and HER2- (TAME)] of locally advanced BC. Twenty patients were prospectively en...

Suppose that F : (R × R, 0) → (R × R, 0) is a smoothly stable, R-level preserving germ which unfolds f : (R, 0) → (R, 0); then f is smoothly stable if and only if we can find a pair of smooth retractions r : (R, 0)→ (R, 0) and s : (R, 0)→ (R, 0) such that f ◦ r = s ◦F . Unfortunately, we do not know whether f will be topologically stable if we can find a pair of continuous retractions r and s. ...

The isomorphism type of the knot quandle introduced by Joyce is a complete invariant of tame knots. Whether two quandles are isomorphic is in practice difficult to determine; we show that this question is provably hard: isomorphism of quandles is Borel complete. The class of tame knots, however, is trivial from the perspective of Borel reducibility, suggesting that equivalence of tame knots may...