نتایج جستجو برای: tau

تعداد نتایج: 20923  

2013
Catherine M. Cowan Amrit Mudher

Aggregation of highly phosphorylated tau into aggregated forms such as filaments and neurofibrillary tangles is one of the defining pathological hallmarks of Alzheimer's disease and other tauopathies. Hence therapeutic strategies have focused on inhibition of tau phosphorylation or disruption of aggregation. However, animal models imply that tau-mediated dysfunction and toxicity do not require ...

2018
Alexander J. Moszczynski Wendy Strong Kathy Xu Ann McKee Arthur Brown Michael J. Strong

OBJECTIVE To investigate whether chronic traumatic encephalopathy (CTE) and CTE with amyotrophic lateral sclerosis (CTE-ALS) exhibit features previously observed in other tauopathies of pathologic phosphorylation of microtubule-associated protein tau at Thr175 (pThr175 tau) and Thr231 (pThr231 tau), and glycogen synthase kinase-3β (GSK3β) activation, and whether these pathologic features are a ...

Journal: :The Journal of biological chemistry 1993
E Köpke Y C Tung S Shaikh A C Alonso K Iqbal I Grundke-Iqbal

The major protein subunit of the paired helical filaments (PHF) of Alzheimer disease (AD) is the microtubule-associated protein tau. Tau is a family of phosphopolypeptides that are abnormally phosphorylated in PHF. In this study, a non-PHF pool of tau abnormally phosphorylated at Ser-199/202, and tau not phosphorylated at this site (AD P-tau and AD tau, respectively) were isolated from the 27,0...

Journal: :Acta Physica Polonica B 2022

The differential rate of the decay Higgs boson ($h$) to a pair $\tau $ leptons with their subsequent in $\tau^-\to \pi^- \nu_\tau$ and $\tau^+\to \pi^+{\bar \nu}_\tau$ channels is studied. Yukawa interaction between $\tau$ assumed include scalar ($S$) pseudoscalar ($PS$) couplings. Angular distributions pions $h\to\tau^- \tau^+\to\pi^-\nu_{\tau}\,\pi^+{\bar are considered. For real values $S$ $...

Journal: :Neuron 2010
Brian R. Hoover Miranda N. Reed Jianjun Su Rachel D. Penrod Linda A. Kotilinek Marianne K. Grant Rose Pitstick George A. Carlson Lorene M. Lanier Li-Lian Yuan Karen H. Ashe Dezhi Liao

The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related deficits develop not from the loss of synapses or neurons, but rather as a result o...

2017
Kaoru Yamada

The pathological aggregation of tau protein is a hallmark of a set of neurodegenerative diseases collectively referred to as tauopathies. Tau aggregates independently in each neuron, but this aggregation can also occur in a non-cell autonomous manner in which aggregated tau is transmitted from one cell to another. Such trans-cellular propagation is initiated by the uptake of extracellular tau, ...

2016
Robert Y. K. Lai Charles R. Harrington Claude M. Wischik

Alzheimer's disease is characterized by redistribution of the tau protein pool from soluble to aggregated states. Aggregation forms proteolytically stable core polymers restricted to the repeat domain, and this binding interaction has prion-like properties. We have compared the binding properties of tau and tubulin in vitro using a system in which we can measure binding affinities for proteins ...

Journal: :Neuron 2015
Yingjun Zhao I-Chu Tseng Charles J. Heyser Edward Rockenstein Michael Mante Anthony Adame Qiuyang Zheng Timothy Huang Xin Wang Pharhad E. Arslan Paramita Chakrabarty Chengbiao Wu Guojun Bu William C. Mobley Yun-wu Zhang Peter St. George-Hyslop Eliezer Masliah Paul Fraser Huaxi Xu

Progressive supranuclear palsy (PSP) is a movement disorder characterized by tau neuropathology where the underlying mechanism is unknown. An SNP (rs1768208 C/T) has been identified as a strong risk factor for PSP. Here, we identified a much higher T-allele occurrence and increased levels of the pro-apoptotic protein appoptosin in PSP patients. Elevations in appoptosin correlate with activated ...

2014
Naruhiko Sahara Miyuki Murayama Makoto Higuchi Tetsuya Suhara Akihiko Takashima

Alzheimer's disease is a progressive dementia that is characterized by a loss of recent memory. Evidence has accumulated to support the hypothesis that synapses are critical storage sites for memory. However, it is still uncertain whether tau protein is involved in associative memory storage and whether tau is distributed in mature brain synapses. To address this question, we examined the synap...

Journal: :The Journal of biological chemistry 2007
Hirofumi Aoyagi Masato Hasegawa Akira Tamaoka

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), an autosomal, dominantly inherited neurodegenerative disorder caused by tau gene mutations, is neuropathologically characterized by intraneuronal filamentous inclusions of hyperphosphorylated tau protein. Biochemical and immunocytochemical analyses have shown that only mutant tau is deposited in patients harboring P301L...

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