نتایج جستجو برای: tc17

تعداد نتایج: 181  

2017
Daniela Carlos Frederico R. C. Costa Camila A. Pereira Fernanda A. Rocha Juliana N. U. Yaochite Gabriela G. Oliveira Fernando S. Carneiro Rita C. Tostes Simone G. Ramos Dario S. Zamboni Niels O. S. Camara Bernhard Ryffel João S. Silva

Although a correlation between polymorphisms of NOD-like receptor family-pyrin domain containing 3 (NLRP3) and predisposition to type 1 diabetes (T1D) has been identified, the potential function and activation of the NLRP3 inflammasome in T1D have not been clarified. The present study shows that non-obese diabetic mice exhibited increased NLRP3, and pro-IL-1β gene expression in pancreatic lymph...

2016
Christina L. Graves Jian Li Melissa LaPato Melanie R. Shapiro Sarah C. Glover Mark A. Wallet Shannon M. Wallet

Environmental factors contribute to the initiation, progression, and maintenance of type 1 diabetes (T1D), although a single environmental trigger for disease has not been identified. Studies have documented the contribution of immunity within the gastrointestinal tract (GI) to the expression of autoimmunity at distal sites. Intestinal epithelial cells (IECs) regulate local and systemic immunol...

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