B7-transfectant tubular epithelial cells induce T cell anergy, ignorance or proliferation. We have previously established that interferon (IFN)-y stimulated, antigen-pulsed tubular epithelial cells (TEC) stimulate antigen (Ag) specific activation of T cell hybridomas to express IL-2, In contrast, these Ag pulsed TEC do not stimulate T helper I (Thi) clones to proliferate, but rather render them...

Large-scale TEC perturbations/enhancements observed during the day sectors of major storm periods, 12– 13 February 2000, 23 September 1999, 29 October 2003, and 21 November 2003, were studied using a high resolution GPS network over Japan. TEC enhancements described in the present study have large magnitudes (≥25×1016 electrons/m2) compared to the quiet-time values and long periods (≥120 min). ...

To obtain accurate measurements for brightness temperature from the IIP radiometer, it is necessary to know the temperature of the front-end components especially low noise amplifier (LNA) and microwave terminator during measurements. For this application, all of these components will be placed on a temperature-stabilized metal plate which can be achieved by using a thermoelectric cooler (TEC)....

Developing thymocytes interact with thymic epithelial cells (TECs) through cell-cell interactions, TEC-derived secretory moieties and extracellular matrix (ECM)-mediated interactions. These physiological interactions are crucial for normal thymocyte differentiation, but can be disrupted in pathological situations. Indeed, there is severe thymic atrophy in animals acutely infected with Trypanoso...

The type VI secretion system (T6SS) is a lethal weapon used by many bacteria to kill eukaryotic predators or prokaryotic competitors. Killing by the T6SS results from repetitive delivery of toxic effectors. Despite their importance in dictating bacterial fitness, systematic prediction of T6SS effectors remains challenging due to high effector diversity and the absence of a conserved signature s...

Myeloablative conditioning results in thymic epithelial cell (TEC) injury, slow T-cell reconstitution, and a high risk of opportunistic infections. Keratinocyte growth factor (KGF) stimulates TEC proliferation and, when given preconditioning, reduces TEC injury. Thymocytes and TECs express androgen receptors, and exposure to androgen inhibits thymopoiesis. In this study, we have investigated wh...

Thymus is crucial for generation of a diverse repertoire of T cells essential for adaptive immunity. Although thymic epithelial cells (TECs) are crucial for thymopoiesis and T cell generation, how TEC development and function are controlled is poorly understood. We report here that mTOR complex 1 (mTORC1) in TECs plays critical roles in thymopoiesis and thymus function. Acute deletion of mTORC1...

Endothelial cell proliferation is a critical event during angiogenesis, regulated by both soluble factors and mechanical forces. Although the proliferation of tumor cells is studied extensively, little is known about the proliferation of tumor endothelial cells (TEC) and its contribution to tumor angiogenesis. We have recently shown that reduced expression of the mechanosensitive ion channel TR...

Signal phase measured by GPS signal processors is crucial for high-resolution range measurement. However, the measured signal phase must be corrected for the the dispersive phase advance imposed by the earth’s ionosphere. Dual-frequency measurements exploit frequency dependence to isolate and correct the ionosphere-induced phase change. The correction is proportional to total electron content (...

PURPOSE To investigate the predictability and accuracy of active cyclotorsion compensation during LASIK for myopia with astigmatism. METHODS Fifty-two eyes of 26 patients were divided into two groups; one group (30 eyes) underwent primary LASIK with torsion error correction (TEC [TEC group]) and 22 eyes underwent LASIK without TEC (control group). The NIDEK EC-5000 CX III excimer laser was us...