OBJECTIVES Recently, several authors reported that Tc-99m DMSA renal scan frequently showed cortical defects of the involved kidneys even in the patients with acute pyelonephritis who did not show abnormal findings in the ultrasonography and intravenous pyelography (IVP). METHODS In order to evaluate the utilities of Tc-99m DMSA renal scan and the clinical meaning of cortical defects in the T...

An electrophoretic procedure is outlined for the determination of the number of ligands bound to technetium-99m radiopharmaceuticals. The approach involves use of ligands that will complex technetium in a similar fashion but that differ in charge. This approach was applied experimentally to dimercapto ligands in which the ligating sulfur atoms are separated by a flexible three-carbon chain (1,3...

Multiple myeloma (MM) is a clonal B-lymphocyte neoplasm of terminally differentiated plasma cells. Imaging modalities which allow the recognition of the effects of myeloma cells on the skeletal system have been utilized for a long time. Herein, we represent a patient with generalized osteoporosis and hypercalcemia, who was referred for parathyroid scan, in whom the widespread bone marrow techne...

A 10-year-old boy with a history of bloody discoloration of urine following recent appendectomy was referred to our department for urinary leakage/fistula evaluation. A renal Technetium-99m-L,L-ethylenedicysteine (99mTc-EC) scintigraphy was performed. After injection of radiotracer, a focus of activity appeared in the supralateral part of the right kidney which was confirmed as accum...

Background: Screening for patients at risk of renal scarring is a challenge in children with acute pyelonephritis (APN). Diuretic Tc-99m mercaptoacetyltriglycine (MAG3) scintigraphy with zero time injection of furosemide (MAG3-F0) was observed to display focal parenchymal disorders. The advantages of MAG3 include: lower radiation dose and short duration of the test. The aim of this study was to...

OBJECTIVE This study aimed to explore the diagnostic role of a new dual receptor-targeted probe, integrin ανβ3 and gastrin releasing peptide receptor (GRPR) targeted peptide Glu-c(RGDyK)-bombesin (RGD-BBN) labeled with technetium-99m ((99m)Tc-RGD-BBN), using single photon emission tomography/computed tomography (SPET/CT) in the detection of breast tumor in comparison to ultrasound (US). SUBJE...

BACKGROUND The authors prospectively evaluated the correlation between technetium-99m methoxyisobutyl isonitrile ((99m) Tc-MIBI) accumulation in tumors and response to induction chemotherapy in patients with nasopharyngeal carcinoma (NPC). METHODS Eighty-six patients with locally advanced NPC underwent single-photon emission computed tomography 15 minutes after an intravenous injection of 740...

uclear imaging of the heart is fast emerging as a valuable and widely used non-invasive procedure, that reveals vital information about cardiac structure, physiology, perfusion and metabolism. Commonly perfonned nuclear imaging techniques in cardiology are radionuclide ventriculography (RNV) done by labelling autologous red blood cells with Technetium-99m (Tc-. 99m) and myocardial perfusion ima...

Recent shortages of molybdenum-99 ((99)Mo) have led to an examination of alternate production methods that could contribute to a more robust supply. An electron accelerator and the photoneutron reaction were used to produce (99)Mo from which technetium-99m ((99m)Tc) is extracted. SPECT images of rat anatomy obtained using the accelerator-produced (99m)Tc with those obtained using (99m)Tc from a...

© 2008 Elsevier. All rights reserved. The pentavalent Tc-99m dimercaptosuccinic acid (Tc99m (V) DMSA, Tc(V)-DMSA) radiotracer has become more widely used. The accumulation of Tc(V)-DMSA in tumors was first reported in 1981 [1], and this tracer has subsequently been shown to localize in a variety of tumors [2,3]. Tc(V)-DMSA has also been used to depict abscesses and other inflammatory lesions [4...