The advent of early absorption, distribution, metabolism, excretion, and toxicity (ADMET) screening has increased the attrition rate of weak drug candidates early in the drug-discovery process, and decreased the proportion of compounds failing in clinical trials for ADMET reasons. This paper reviews the history of ADMET screening and its place in pharmaceutical development, and central nervous ...

We study the instantaneous nonlinear index change in Al,,,Gac,sAs waveguides below the twophoton absorption edge and find Sphase shifts with 80 pJ, 0.4 ps pulses at wavelengths near 1.6 pm. These large phase shifts are obtained with less than 1 dB of loss from multiphoton absorption. Our results indicate that AlGaAs waveguides, which have a mature fabrication technology, can be used as compact ...

We present airborne measurements of a novel eye-safe spectrally broadband LIDAR capable of dealing with the atmospherically-induccd variations in CO2 absorption using a Fabry-Perot based detector. The Fabry-Perot solid etalon in the receiver part is tuned to match the wavelength of several CO2 absorption lines simultaneously. The broadband technique tremendously reduces the requirement for sour...

A novel thermal light based scheme utilizing the second-order coherence is proposed for ultra-high accuracy synchronization of two distant clocks. By using two-photon absorption, which involves an almost simultaneous absorption of two photons within a maximum delay given by the Heisenberg principle, the second-order coherence at a femtosecond scale for a real thermal source has been observed (B...

Quantum dot solar cells, as a promising candidate for the next generation solar cell technology, have received tremendous attention in the last 10 years. Some recent developments in epitaxy growth and device structures have opened up new avenues for practical quantum dot solar cells. Unfortunately, the performance of quantum dot solar cells is often plagued by marginal photon absorption. In thi...

Gas Chromatography (GC) is a mature analytical technology used predominately for separating and quantifying the components of complex organic chemical mixtures. The addition of mass selective detectors has extended the use of GC to include compound identification. A wide range of columns and sample introduction techniques allow GC to solve most analytical problems for volatile and semi-volatile...

Current practice guidelines recommend administration of oral isotretinoin with high-fat meals, which may pose issues with patient compliance. Isotretinoin-Lidose (Epuris™), approved by Health Canada in November 2012 and scheduled for commercial release June 2013, is based on novel lipid encapsulation technology (Lidose®) to enclose isotretinoin, thereby increasing drug absorption during fasted ...

Antenna-coupled micro-bridge structure is proven to be a good solution to extend infrared micro-bolometer technology for THz application. Spiral-type antennas are proposed in 25 μm × 25 μm micro-bridge structure with a single separate linear antenna, two separate linear antennas, or two connected linear antennas on the bridge legs, in addition to traditional spiral-type antenna on the support l...

Despite fruitful studies on knowledge flow and interdisciplinarity, there are few investigations on knowledge flow in humanities and social sciences (HSS) and how knowledge from science and technology diffuses to HSS sub-disciplines. Based on Chinese and English articles in HSS, this study explored knowledge flow in China’s HSS with an analysis of Chinese and English publications from 1998 to 2...