WHAT IS KNOWN AND OBJECTIVE Telmisartan is an angiotensin receptor blocker (ARB) originally developed for the treatment of hypertension. It can also partially activate peroxisome proliferator-activated receptor (PPAR)-γ, which may improve insulin sensitivity. This effect may prove useful in hypertensive patients with insulin resistance or diabetes mellitus. Such activity is more marked than tha...

Introduction. Telmisartan is widely used in clinical practice during hypertension treatment. It a specific angiotensin II receptor antagonist (type AT1), effective at oral intake, A bioequivalence study of Telzap ® and Mikardis was conducted with 60 volunteers. Aim. The purpose the trial comparative pharmacokinetics evidence (telmisartan, tablets 80 mg, Boehringer Ingelheim International GmbH, ...

angiotensin II type 1 (AT1) receptor antagonist have been widely used by patients with high blood pressure, kidney disease and heart failure. Telmisartan (BIBR 277) is the most recently marketed AT1 receptor antagonist. 2) Telmisartan lowers blood pressure though blockade of the renin-angiotensin-aldosterone system. The efficacy of telmisartan has been shown to be at least equivalent to that of...

Angiotensin-converting enzyme (ACE) inhibitors have favourable effects on hypertension and diabetic nephropathy, but persistent use may result in incomplete blockade of the renin-angiotensin system. Long-term effects of dual blockade using the ACE inhibitor lisinopril and the long-acting angiotensin II receptor blocker (ARB) telmisartan on blood pressure and albumin excretion rate (AER) were ev...

BACKGROUND/AIMS Anti-glomerular basement membrane (GBM) nephritis is characterized by activation of the renin-angiotensin system. This study aimed to determine the question of whether a temporary angiotensin II blockade at the initial stage of anti-GBM nephritis is able to attenuate the disease as well as differences in renoprotection among angiotensin II receptor blockers (ARBs) with distinct ...

AIM AND BACKGROUND The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of telmisartan and metoprolol succinate in combined tablet dosage form. MATERIALS AND METHODS The method is based on the absorbance correction equations for analysis of both the drugs using methanol as solvent. Telmisartan ...

BACKGROUND AND OBJECTIVE Angiotensin II receptor blockers represent a class of effective and well-tolerated orally active antihypertensive drugs in the general hypertensive population and in diabetic patients. The aim of our study was to investigate the metabolic effects of telmisartan and irbesartan in diabetic subjects treated with rosiglitazone. METHODS We evaluated 188 type 2 diabetic pat...

14 We investigated the effects of telmisartan, the blocker of angiotensin II receptor 1, on 15 the regulation of systolic blood pressure (SBP) and oxidative stress through 16 endothelial nitric oxide (NO) release in spontaneously hypertensive rats (SHR). SHRs 17 randomly received placebo, oral feeding of telmisartan (5 mg/kg or 10 mg/kg) every 18 day and Wistar-Kyoto rats (WKYs) served as normo...

Hypertension is a major cardiovascular (CV) risk factor, and blood pressure (BP)-lowering treatment substantially reduces the risk. This review compares the available clinical evidence from the BP-lowering and CV-outcome studies of telmisartan and perindopril, which are among the most intensively studied members of their respective classes. The PubMed database was searched for telmisartan and p...

Chronic renal failure (CRF) mainly results from kidney fibrosis. Epithelial-to-mesenchymal transition (EMT) occurs in stressed tubular epithelial cells and contributes to renal fibrosis. Transforming growth factor-β1 (TGF-β1) has been shown to initiate and complete the whole EMT process. Peroxisome proliferators-activated receptor-γ (PPAR-γ) exerts anti-inflammatory, anti-fibrotic and vaculo-pr...