We evaluated the effects of phenylalanine on reproductive performance and teratogenesis in mice, as well as we assessed its protective effect in mice treated with an acute dose of cyclophosphamide. Animals were divided into 6 experimental groups (females N = 15/group, males N = 5/group): G1, the negative control group, phosphate-buffered saline; G2, the positive control group, 35 mg cyclophosph...

BACKGROUND Many birth defects are believed to involve gene-environment interactions, although the mechanisms involved are poorly understood. Apoptosis is a common effect of many kinds of environmental stresses on the developing embryo; therefore, mechanisms of teratogenesis may be approached within the context of the cell death program. The p53 tumor suppressor gene encodes a transcription fact...

The use of antiepileptic drugs in pregnancy always presents challenges to doctors and their patients as it may have deleterious effects on the developing embryo. Lamotrigine is most commonly-prescribed drug among the newer antiepileptic drugs; hence, it has been selected for the present review. A number of studies pertaining to the safety of lamotrigine use during pregnancy have been reported, ...

Azarbayjani, F. 2001. Common mechanism for teratogenicity of antiepileptic drugs. Drug induced embryonic arrhythmia and hypoxia-reoxygenation damage. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculy of Pharmacy 253. 54 pp. Uppsala.

Recent advances in the basic sciences and epidemiology indicate that impacts of classically described cannabinoid genotoxicity may be much more clinically significant than previously supposed. Here we summarize evidence from epigenomics, recent epidemiological studies other areas exploring exponential many cannabinoids on cancer, congenital anomalies aging. Together these findings transgenerati...