To measure the testicular toxicity of two fungicides (carbendazim and iprodione), alone or in a mixture, we used a rat ex vivo model of seminiferous tubules, greatly reducing the number of rodents used, in accordance with the 3R rule (Replacement, Reduction, and Refinement). This model allows the representation of puberty, a critical life period with regard to endocrine disruptors. The cellular...

AIMS To investigate the mechanisms of α-zearalanol (Zeranol)-induced male reproductive toxicity, the effects of Zeranol on spermatogenesis and sex hormone levels of male mice were studied. METHODS Forty healthy sexually mature male Kunming mice were randomly divided into four groups. The mice were mock-treated or treated with Zeranol 25, 50 or 100 mg/kg via oral gavage for 35 days. The epidid...

Benzo-a-pyrene (BaP) exposure is toxic to the reproductive systems. The beneficial effects of taurine (TAU) against BaP-induced toxicity in epididymis and testes rats co-treated with BaP (10 mg/kg) TAU at doses 100 200 mg/kg for 28 successive days are reported this study. Co-treatment significantly alleviated decreases sperm quality, hormones, oxidative stress inflammatory biomarkers. also less...

Nicotine (NIC) adversely influences male reproductive system. Achillea millefolium (Achm) as a medicinal plant is highly regarded for its antioxidant and anti-inflammatory properties. The present study was conducted to assess whether Achm inflorescences alcoholic extract could serve as a protective agent against reproductive toxicity in NIC-exposed male rats. Adult male rats were randomly divid...

introduction: pyrethroids are important insecticides because of their high activity and low mammalian toxicity. some studies have demonstrated that these insecticides, especially compounds with an -cyano group, produce toxic effects on various biological systems. deltamethrin (dtm) is a type ii synthetic pyrethroid insecticide containing -cyano group and is used worldwide in agriculture, home...

Background: Cyclosporine-A(CsA) is an immunosuppressive polypeptide which is produced byTolypocladium inflatum gams and can cause infertility. Satureja hortensis or summer savory is a one year plant from Lamiaceae family which is used as a motive drug, anti-bloat, anti-infection and sexual power enhancer. According to positive effects of S. hortensis and negative effects of CsA we will evaluate...

Cisplatin is a chemotherapeutical agent that is highly effective in the treatment of solid organ tumours, such as ovarian, testicular, bladder, non-small cell pulmonary, and head and neck tumours. The main side effects associated with the use of cisplatin are gastrointestinal toxicity, nephrotoxicity, myelotoxicity, peripheral neurotoxicity and ototoxicity. Ototoxic lesions cause bilateral neur...