Background: Diabetes mellitus is a degenerative disease that has deleterious effects on male reproductive function, possibly through an increase in oxidative stress. Walnut is known as an antioxidant that may be effective on decreasing free radicals. The aim of this study was to evaluate walnut consumption effects on testis and prostate in diabetic Wistar male rats induced by STZ. Materials and...

Testicular damage is one of the most hazardous effects as it’s associated with azoospermia. Busulfan (Bu) a highly toxic chemotherapeutic drug that affects testis. Thirty male Swiss albino mice divided into six groups 5 animals each. Control (oral 0.9% saline daily for 75 days); Mel (20 mg/kg/day orally 30 ZnO NPs (5 i.p. BU (single injection 40 mg/kg and then left 45 + dose days followed by 20...

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes. Because ROS/RNS can induce oxidative injury and act in redox signaling, enzymes metabolizing them will inherently promote either health or disease, depending on the physiological context. It is thus misleadi...

In order to find out the effect of chronic ethanol administration on testicular antioxidant system and steroidogenic enzyme activity, male rats fed with ethanol 1.6g/kg body weight per day for four weeks were studied. Besides a drastic reduction in body and testis weight, there was decrease in ascorbic acid, reduced glutathione and activities of superoxide dismutase, catalase, glutathione reduc...

Background: Because of the observed protective effect of melatonin against TLE and the putative role of melatonin to influence neuroendocrine-gonadal axis, we tried to find out whether initiating the melatonin treatment after induction of Status Epilepticus (SE) and all along the different phases of epileptogenesis process, might be able to protect the testes and sperm against devastating effec...

As we already know, the male reproductive system requires less energetic investment than the female one. Nevertheless, energy balance is an important feature for spermatozoa production in the testis and for spermatozoa properties after ejaculation. The 5'-AMP-activated protein kinase, AMPK, is a sensor of cell energy, that regulates many metabolic pathways and that has been recently shown to co...

Background: Cadmium toxicity is an environmental health menace in developing countries, which can result damage to the male reproductive system. The mechanisms of cadmium include increase lipid peroxidation, depletion glutathione, reduction protein-bound sulfhydryl groups, and oxidative stress. Agnus castus has been differently reported for its strong antioxidant potential reproductive-enhancin...

The current study aimed to evaluate the efficacy of simultaneous administration Zingiber officinale (ginger) and Cinnamomum cassia (cinnamon) extracts in mitigating testicular changes associated with diabetes mellitus rats investigate its molecular mode action. After induction using streptozotocin, 36 male were divided six groups namely control, diabetic, metformin-treated, cinnamon-treated, gi...

Cadmium (Cd) is an environmental and industrial pollutant that affects the male reproductive system. Exposure to cadmium metal is known to induce the formation of reactive oxygen species (ROS) like superoxide radical, hydroxyl ion and hydrogen peroxide. Vitamin E is a lipid phase antioxidant & Vitamin C acts as a potent water soluble antioxidant by scavenging reactive oxygen species. The purpos...

Joint destruction in rheumatoid arthritis (RA) is due to tissue injury in the area caused by inflammatory reactions, release of MMPs and free radicals produced by neutrophils and macrophages. The control of free radical production may have therapeutic roles thus the study was done to check the status of lipid peroxidation product malondialdehyde (MDA) and a few antioxidant enzymes in RA patient...