BACKGROUND Acanthosis nigricans is a feature of several syndromes caused by activating mutations of the fibroblast growth factor receptor 3 gene (FGFR3), including Crouzon syndrome with acanthosis nigricans, thanatophoric dysplasia, and severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN syndrome). OBSERVATIONS We describe a healthy 4-year-old African American girl...

Correspondence should be addressed to Tsing-San Hsu, [email protected] Received 8 September 2010; Accepted 18 October 2010 Academic Editor: Julio Rossi Copyright q 2010 Tsing-San Hsu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly c...

Accurate assessment of trustworthiness is fundamental to successful and adaptive social behavior. Initially, people assess trustworthiness from facial appearance alone. These assessments then inform critical approach or avoid decisions. Individuals with Williams syndrome (WS) exhibit a heightened social drive, especially toward strangers. This study investigated the temporal dynamics of facial ...

Correspondence should be addressed to Tsing-San Hsu, [email protected] Received 9 October 2009; Accepted 12 February 2010 Academic Editor: Kanishka Perera Copyright q 2010 Tsing-San Hsu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properl...

Genetics of Dyslipidemia Diego García-Giustiniani1,2 and Ricardo Stein3,4,5 Health in Code1, La Coruña, Spain; Grupo de Investigación Cardiovascular de La Universidad de La Coruña, La Coruña, Spain2; Grupo de Pesquisa em Cardiologia do Exercício do Hospital de Clínicas de Porto Alegre3; Serviço de Cardiologia do Hospital de Clínicas de Porto Alegre – Universidade Federal do Rio Grande do Sul4; ...

Evidence suggests engaging in regular physical activity (PA) can have beneficial outcomes for adults with type 2 diabetes (TD2), including weight loss, reduction of medication usage and improvements in hemoglobin A1c (HbA1c)/fasting glucose. While a number of clinical-based PA interventions exist, community-based approaches are limited. The objective of this study is to conduct a systematic rev...

INTRODUCTION in 2008, the British Geriatrics Society (BGS) developed the Recommended Undergraduate Curriculum in Geriatric Medicine. This was subsequently mapped to the second edition of Tomorrows' Doctors (TD2, 2003). Following the publication of the third edition of Tomorrow's Doctors in 2009 (TD3), the mapping exercise was repeated to verify the extent to which the updated General Medical Co...

PURPOSE In a meta-analysis of the literature we evaluated the present knowledge of the material properties of cortical and cancellous bone to answer the question whether the available data are sufficient to realize anisotropic finite element (FE)-models of the proximal femur. MATERIAL AND METHOD All studies that met the following criteria were analyzed: Young's modulus, tensile, compressive a...

[1] The rupture of the Sumatra earthquake (Mw = 9.0) is complex and quite difficult to estimate using classical source inversion methods due to the exceptional rupture duration. To fix the problem of geographical extent and rupture duration, we use array processing of hydroacoustic and regional seismic data. The CMAR-seismic array and the Diego Garcia hydroacoustic station (H08S) installed by t...