BACKGROUND Ethanol production from lignocellulosic feedstocks (also known as 2nd generation or 2G ethanol process) presents a great potential for reducing both ethanol production costs and climate change impacts since agricultural residues and dedicated energy crops are used as feedstock. This study aimed at the quantification of the economic and environmental impacts considering the current an...

Shiga toxin-producing Escherichia coli (STEC) are characterized by the production of Shiga toxins (Stx) encoded by temperate bacteriophages. Stx production is linked to the induction of the phage lytic cycle. Several stx variants have been described and differentially associated with the risk of developing severe illness. The variant named stx(2g) was first identified in a STEC strain isolated ...

AIM Metalloproteinases (MMPs) are a family of multifunctional proteins which have been shown to be up-regulated in various types of cancer. However, the contribution of MMP1 genotype to oral cancer has not been elucidated. This study aimed to evaluate the contribution of MMP1 promoter 1607 genotype to the risk of oral cancer. MATERIALS AND METHODS In this case-control study, MMP1 genotype and...

BACKGROUND Primary open angle glaucoma (POAG) is considered to be a leading cause of irreversible blindness worldwide. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) have been extensively studied as POAG risk factors. Recently, several single-nucleotide polymorphisms (SNPs) for MMPs and TIMPs encoding genes have been reported in POAG patients. The aim of this study was to investi...

Chimeric-antigen-receptor (CAR) T-cell therapy for CD19-expressing B-cell malignancies is already widely adopted in clinical practice. On the other hand, development of CAR-T-cell its nascent stage. One potential targets CD26, to which we have developed and evaluated efficacy safety humanized monoclonal antibody YS110. We generated second (CD28) third (CD28/4-1BB) generation CD26-targeted CAR-T...

Actualmente existe un crecimiento mundial en el consumo de energía y son los biocombustibles la alternativa viable para reducir dependencia combustibles fósiles, minimizar impacto ambiental negativo e incrementar uso fuentes alternativas. El etanol ha sido parte esta solución, su producción industrial evoluciona según tratamiento aplicado a materia prima. La segunda generación (2G) partir del m...

For a positive integer g, let Sp2g(R) denote the group of 2g× 2g symplectic matrices over a ring R. Assume g ≥ 2. For a prime number , we give a self-contained proof that any closed subgroup of Sp2g(Z ) which surjects onto Sp2g(Z/ Z) must in fact equal all of Sp2g(Z ). The result and the method of proof are both motivated by group-theoretic considerations that arise in the study of Galois repre...