Following p.o. administration to rats bearing advanced colorectal carcinoma, Ftorafur (FT) is converted to 5-fluorouracil (FUra) by microsomal P450 in the liver. To optimize the therapeutic selectivity of the FUra generated from FT, three approaches were utilized: (a) inhibition of FUra degradation to dihydrofluorouracil by uracil as an alternative substrate for uracil reductase in the molar ra...

in order to determine the genetics of barley lines for freezing resistance based on crown survival percentage an experiment was carried out as a split plot design on the basis of randomized complete blocks with two replications. forty barley lines were assigned in subplots and five freezing temperatures (-8, -11, -13, -15 and -17 ˚с) were allocated in main plots. the results showed significant ...

in order to evaluate the effect of freezing stress on electrolyte leakage of three mooseers’ (allium altissimum regel.) ecotypes (shirvan, kalat and tandoureh), a factorial experiment based on completely randomized design with three replications was carried out under the controlled conditions in the faculty of agricultural, ferdowsi university of mashhad, iran, during 2009. plants were grown in...

The overall disposition and hepatobiliary transport of BQ-123, an anionic cyclopentapeptide, and three analogs were examined in rats in vivo. Total body clearance (CLtotal) and biliary excretion clearance (CLbile, p) exhibited 4- to 8-fold differences between the compounds, with those for BQ-485 and compound A having the highest and lowest values, respectively. The CLbile, p values of BQ-485, B...

BACKGROUND Lowered testosterone level in CRF patients is associated with elevated risk of death due to cardiovascular reasons, and is influenced by many factors, including acid-base balance disorders. AIMS evaluation of testoste-rone concentration (TT) and free testosterone concentration (fT) in pre-dialysis and dialysis patients; assessment of TT and fT relationships with biochemical paramet...

Diaphorina citri Kuwayama (Psyllidae: Hemiptera) and Aphis gossypii Glover (Aphididae; are destructive sap-feeding pests of citrus cotton, respectively. This study assessed the toxicity potential indigenous flora Soon valley surrounding salt range (Punjab, Pakistan) against D. A. gossypii. Among acetone extracts 40 plant species, Mentha longifolia (L.) Huds., Melilotus officinalis Pall., Nerium...