Little is known about where microRNAs (miRNAs) regulate their targets within the cell. In this issue, Li et al. identify a new player in the plant miRNA pathway that implicates the endoplasmic reticulum in miRNA-mediated gene silencing.

background and aims: visit quality is a crucial component of patient-physician interaction that its inadequacy can negatively influence the diagnosis and treatment efficiency. the waiting time and visit length are important determinants of quality in the outpatient care setting. thus, the aim of this study was to determine waiting time and visit length and to compare them before implementation ...

One of the most interesting findings of hypertension research in the past 10 years has been that the cardiovascular protective effects of antihypertensive drugs depend not only on the mean blood pressure (BP) values achieved during treatment but also on the consistency of BP control between on-treatment visits. This was suggested in 2007 by the observation that in patients with hypertension and...

One of the most interesting findings of hypertension research in the past 10 years has been that the cardiovascular protective effects of antihypertensive drugs depend not only on the mean blood pressure (BP) values achieved during treatment but also on the consistency of BP control between on-treatment visits. This was suggested in 2007 by the observation that in patients with hypertension and...

Let v,(n) be the minimum average number of pairwise comparisons needed to find the k-th largest of n numbers (k > 2) , assuming that all n! orderings are equally likely. D. W. Matula proved that, for sme absolute constant c , Vk(n)-n 5 c k log log n as n 3 = . In the -present-paper, we show that there exists an absolute constant c' > 0 such that v,(n)-n 2 c' k log log n as n 3 w , proving a con...

The notion of solvable structure is generalized in order to exploit the presence an algebra symmetries for a kth-order ordinary differential equation with k > 3. In this setting, knowledg...