Morphinan alkaloids are the most powerful narcotic analgesics currently used to treat moderate to severe and chronic pain. The feasibility of morphinan synthesis in recombinant Saccharomyces cerevisiae starting from the precursor (R,S)-norlaudanosoline was investigated. Chiral analysis of the reticuline produced by the expression of opium poppy methyltransferases showed strict enantioselectivit...

We have studied the cytotoxic nature of two groups of narcotic analgesics. Group 1 consists of the opioids, morphine, codeine, hydromorphone, thebaine, and etorphine. Group II contains but two phenylpiperidine-type narcotics, fentanyl and sufentanil. To measure cytotoxicity, three different bioassays were employed using an established line of human cells. Specifically, the effects of narcotic a...

Introduction of drugs (colloquially known as painkillers) used to relieve pain (achieve analgesia). Analgesic drugs act in various ways on the peripheral and central nervous systems; they include paracetamol (acetaminophen), the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, narcotic drugs such as morphine, synthetic drugs with narcotic properties such as tramadol, and v...

A previously unknown disease which causes severe vein thickening and inward leaf curl was observed in a number of opium poppy (Papaver somniferum L.) plants. The sequence analysis of full-length viral genome and associated betasatellite reveals the occurrence of Ageratum enation virus (AEV) and Ageratum leaf curl betasatellite (ALCB), respectively. Co-infiltration of cloned agroinfectious DNAs ...

Buprenorphine is a thebaine derivative used in the treatment of heroin and other opiate addictions. In this study, the selective probe reactions for each of the major hepatic cytochromes P450 (P450s) were used to evaluate the effect of buprenorphine and its main metabolite norbuprenorphine on the activity of these P450s. The index reactions used were CYP1A2 (phenacetin O-deethylation), CYP2A6 (...

BACKGROUND Buprenorphine, a synthetic molecule derived from thebaine, has been commercialized in France since 1987 as a substitute treatment for pharmacodependence on opiates. Hepatotoxicity is poorly documented, since only few cases of hepatic injury have been reported. METHODS We report seven cases of acute cytolytic hepatitis due to buprenorphine. All patients were former drug addicts by t...

Poppy seed is an oilseed obtained from the opium plant (Papaver somniferum). It is one of the oldest known painkillers consisting of many alkaloids (morphine, codeine etc.) and is rich in protein and calcium. The morphine content of poppy seed intended for use in food recently have raised major concern due to intoxication in maximum limits. The federal institute for risk assessment (BFR) derive...

Aims: Breast cancer is the most common type of among women and ranks second causes female death in world. In order to find a solution breast cancer, different studies are being conducted for treatment effects drugs substances on this disease intensively investigated. Boric acid has been shown control proliferation certain types cells.Noscapine one ingredients Papaver somniferum (opium). It was ...