Hepatocellular carcinoma (HCC) is the fifth most common malignant disease and the third leading cause of cancer- associated deaths worldwide, and is characterized by a dismal prognosis. Despite the significant improvements achieved in liver transplantation, surgical resection, transcatheter arterial chemoembolization (TACE) and local ablative therapies such as percutaneous ethanol injection (PE...

LESSONS LEARNED Percutaneous thermal ablation combined with in situ granulocyte-macrophage colony-stimulating factor cytokine therapy was technically feasible and well tolerated.No significant clinical or immunologic responses were seen. BACKGROUND Melanoma tumor-derived heat-shock proteins (HSPs) and HSP-peptide complexes can elicit protective antitumor responses. The granulocyte-macrophage ...

Thermal ablation is a promising mechanism to increase permeability of the skin's outer barrier layer of stratum corneum while sparing deeper living tissues. In this study, finite element modeling predicted that the skin surface should only be heated on the microsecond timescale in order to avoid significant temperature rises in living cells and nerve endings in deeper tissue. To achieve such sh...

OBJECTIVE The purpose of this study was to investigate the morphological changes of bovine mandibular bone following Er,Cr:YSGG laser irradiation in different methods in vitro. BACKGROUND DATA Recently, an erbium, chromium/yttrium, scandium, garmet (Er,Cr:YSGG) laser device that emits a laser beam at the wavelength of 2.78 micro m was introduced. This type of infrared laser proved to ablate d...

BACKGROUND The character of ablation processes with high-frequency electrical current is similar in most biological tissues; however, quantitative characteristics are very different. Consequently, mathematical models of the process have a lot of specific aspects. In this study, we developed mathematical model of radiofrequency ablation in liver tissues with experimental validation of model in e...

BACKGROUND Thermal and mechanical high intensity focused ultrasound (HIFU) ablation techniques are in development for non-invasive treatment of cancer. However, knowledge of in vivo histopathologic and immunologic reactions after HIFU ablation is still limited. This study aims to create a setup for evaluation of different HIFU ablation methods in mouse tumors using high-field magnetic resonance...

Aggravated behaviors of hepatocellular carcinoma (HCC) will occur after inadequate thermal ablation. However, its underlying mechanisms are not fully understood. Here, we assessed whether the increased matrix stiffness after thermal ablation could promote the progression of residual HCC. Heat-treated residual HCC cells were cultured on tailorable 3D gel with different matrix stiffness, simulati...

Although only limited long-term studies evaluating thermal ablation of renal masses have been performed, it appears that thermal ablation has a comparable 5-year success rate to that of partial or total nephrectomy. This technique is often used in patients who are not good candidates for partial or total nephrectomy. Contrast-enhanced ultrasound (CEUS) has been recently approved by the Food and...

PURPOSE To investigate the prognostic value of preoperative absolute lymphocyte count (ALC) in recurrent hepatocellular carcinoma (RHCC) following thermal ablation. MATERIALS AND METHODS We retrospectively analyzed the relationship between preoperative ALC and the clinicopathologic factors and long-term prognosis in 423 RHCC patients who underwent curative thermal ablation. Correlation analys...

PURPOSE OF THE STUDY To evaluate postoperative pain after mini-invasive surgical treatment for dysfunctional uterine bleeding (DUB) with transcervical endometrial resection or thermal ablation balloon. MATERIALS AND METHODS A longitudinal observational study, analyzing 47 women affected by DUB who underwent endometrial ablation was conducted. The authors collected evaluation of pelvic pain at...